1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (1:1)

Basic Information

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CAS Number

5370-01-4

Molecular Formula

C11H18ClNO

Molecular Weight

215.72 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

200.0 to 205.0 deg-C

Boiling Point

271.5 °C at 760 mmHg

Density

0.979

Flash Point

112.2 °C

Solubility

ethanol: 50 mg/mL

SMILES

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CC1=C(C(=CC=C1)C)OCC(C)N.Cl

InChI

InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H

InChIKey

NFEIBWMZVIVJLQ-UHFFFAOYSA-N

LogP

2.4512400000000003

pKa

9.0(at 25℃)

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

139

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Toxicity

LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast)

Synonyms & References

English

KO-1173 CL
SB79359
BCP28602
Prestwick_666
MEXILETINE HYDROCHLORIDE [USP MONOGRAPH]
1-Methyl-2-(2,6-xylyloxy)ethylammonium chloride
MLS001056756
NC00682
NCGC00094121-02
MLS002548872
SMR000326711
Mexiletine hydrochloride ( ge 98%)
LP00784
Pharmakon1600-01503929
MEXILETINE HYDROCHLORIDE (USP IMPURITY)
1-(2,6-Dimethylphenoxy)-2-aminopropane hydrochloride
Mexiletine (hydrochloride)
MEXILETINE HYDROCHLORIDE (MART.)
HY-A0093
M 2727
Mexiletine hydrochloride, United States Pharmacopeia (USP) Reference Standard
2-PROPANAMINE, 1-(2,6-DIMETHYLPHENOXY)-, HYDROCHLORIDE (1:1)
SR-01000075986-1
Z2237335016
Tox21_111249_2
606D60IS38
1-(2,6-dimethylphenoxy)propan-2-amine;hydrochloride
KO-1173
MEXILETINE HYDROCHLORIDE (USP MONOGRAPH)
SCHEMBL42226
Tox21_500784

MDL Number

MFCD00216024

Customs Code

2922199090

FAQ

What are the physical and chemical properties of 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4)?

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4) is a colorless or white crystalline solid. The molecular weight is approximately 305.45 g/mol. It has a high solubility in water and organic solvents. This compound shows basic reactivity due to the presence of the protonated amine group.

How is 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4) typically synthesized?

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4) is typically synthesized by the reaction of 2,6-dimethylphenol with 2-propanamine in the presence of a strong acid catalyst, such as hydrochloric acid. The reaction proceeds with high selectivity and yield under mild conditions.

What industries use 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4)?

1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in polymer chemistry and as a component in sensor technology.

What precautions should be taken when handling 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4)?

When handling 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (CAS: 5370-01-4), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Ensure good ventilation by using a fume hood. Follow standard laboratory safety procedures and keep a safety data sheet (SDS) readily available for reference in case of spills or accidents.