Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid

Basic Information

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CAS Number

53572-98-8

Molecular Formula

C6H4N2O2S

Molecular Weight

168.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

233-234 ºC

SMILES

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C1=CSC2=NC(=CN21)C(=O)O

InChI

InChI=1S/C6H4N2O2S/c9-5(10)4-3-8-1-2-11-6(8)7-4/h1-3H,(H,9,10)

InChIKey

BAKIBSRDBASFAQ-UHFFFAOYSA-N

LogP

1.0939999999999999

Topological Polar Surface Area

54.599999999999994 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

187

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

FS-1398
MFCD03419463
AKOS000276562
Imidazo[2 pound not1-b]thiazole-6-carboxylic acid
53572-98-8
DTXSID20374755
SCHEMBL496759
A870691
BAKIBSRDBASFAQ-UHFFFAOYSA-N
FT-0764672
J-521519
imidazo[2,1-b]thiazole-6-carboxylic acid, AldrichCPR
imidazo[2,1-b][1,3]thiazole-6-carboxylic acid
Imidazo[2,1-b]thiazole-6-carboxylicacid
CS-W006813
Imidazo[1,2-a]thiazole-6-carboxylic acid
SY109733
EN300-22365
lmidazo[2,1-b]thiazole-6-carboxylic acid
Imidazo[2,1-b]thiazole-6-carboxylic acid
F1967-0519
Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid
imidazo[2,1-b]1,3-thiazoline-6-carboxylic acid
Imidazo-thiazol-6-carbonsaeure
CHEMBRDG-BB 4401040
IMIDAZO[1,2-A]THIAZOLE-6-CARBOXYLIC ACID
Imidazo[2,1-b]thiazole-6-carboxylicacidHBr

MDL Number

MFCD03419463

Customs Code

2934100090

FAQ

What are the physical and chemical properties of Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8)?

Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8) is a solid crystalline compound with a molecular weight of approximately 238.26 g/mol. It has limited water solubility and is moderately soluble in organic solvents such as DMSO and DMF. The compound exhibits basic properties due to the presence of an amine group. It is stable under normal conditions but may react with strong acids or bases to form salts.

How is Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8) typically synthesized?

Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid can be synthesized via a multistep process involving the condensation of an appropriate thiazole derivative with an imidazole derivative, followed by an acylation step. Common synthetic methods include the use of acetic anhydride or acetyl chloride as acylating agents. The yield and selectivity are typically good, with high purity products achievable under optimized conditions.

What industries use Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8)?

Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8) is used in various industries. In the pharmaceutical sector, it serves as a precursor for drug development, particularly in the field of antiviral and anticancer medications. It also finds applications in the polymer industry for the synthesis of functional polymers and in sensor technology for its ability to detect specific chemical species.

What precautions should be taken when handling Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8)?

When handling Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid (CAS: 53572-98-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize inhalation risks. Spills should be immediately cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.