6-Chloro-3-pyridinamine

Basic Information

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CAS Number

5350-93-6

Molecular Formula

C5H5ClN2

Molecular Weight

128.56 g/mol

EINECS

226-322-3

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

81.0 to 85.0 deg-C

Boiling Point

205.39°C (rough estimate)

Density

1.2417 (rough estimate)

Flash Point

130.7℃

Refractive Index

1.5110 (estimate)

SMILES

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C1=CC(=NC=C1N)Cl

InChI

InChI=1S/C5H5ClN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H2

InChIKey

QAJYCQZQLVENRZ-UHFFFAOYSA-N

LogP

1.3172

pKa

1.94±0.10(Predicted)

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

76.8

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Storage Conditions

Keep in dark place,Inert atmosphere,Room temperature

Sensitiveness

sensitive to light and air

Synonyms & References

English

2-chloro-5-amino pyridine
DTXSID40201716
5-Amino-2-chloropyridine, 98%
AC-1214
5-amino-2-chloro-pyridine
CHEBI:194601
EINECS 226-322-3
5-Amino-2-chloropyridine
FT-0715296
Z335436282
PS-3660
EN300-34596
Q-103406
6-Chloro-3-pyridinamine #
6-chloropyridine-3-amine
A1155
A7784
FT-0619977
AB00661
CS-W007481
NSC81
NS00032774
InChI=1/C5H5ClN2/c6-5-2-1-4(7)3-8-5/h1-3H,7H
6-chloro-pyridin-3-amine
HY-W007481
2-chloro-5-amino-pyridine
NSC-81
6-chloro-3-aminopyridine
AM20061291
2-Chloro-5-aminopyridine
Pyridine, 5-amino-2-chloro-

MDL Number

MFCD00006243

EC Number

226-322-3

Customs Code

29333999

FAQ

What is 6-Chloro-3-pyridinamine (CAS: 5350-93-6)?

6-Chloro-3-pyridinamine (CAS: 5350-93-6) is a pyridine derivative featuring a chlorine atom at the 6th position and an amino group at the 3rd position. Its chemical formula is C5H5ClN2, and it appears as a white crystalline solid. It is soluble in polar solvents like DMSO and ethanol, with a molecular weight of approximately 120.57 g/mol. This compound is commonly used as a precursor in organic synthesis due to its reactivity and structural versatility.

What are the main uses of 6-Chloro-3-pyridinamine (CAS: 5350-93-6)?

6-Chloro-3-pyridinamine (CAS: 5350-93-6) is primarily utilized in pharmaceutical research as an intermediate for drug development, particularly in antihistamine and antipsychotic compounds. It also finds applications in industrial chemistry for producing dyes, pesticides, and other specialty chemicals. In research settings, it serves as a building block for synthesizing bioactive molecules and functional materials due to its aromatic ring and reactive amino group.

Is 6-Chloro-3-pyridinamine (CAS: 5350-93-6) safe?

6-Chloro-3-pyridinamine (CAS: 5350-93-6) requires careful handling due to potential toxicity. Inhalation or skin contact may cause irritation, and ingestion can lead to adverse health effects. Safety standards recommend using appropriate personal protective equipment (PPE), such as gloves and goggles, and working in a well-ventilated area. It is classified as a hazardous chemical under OSHA and EPA guidelines, necessitating adherence to proper disposal and storage protocols to minimize risks.

How should 6-Chloro-3-pyridinamine (CAS: 5350-93-6) be stored?

6-Chloro-3-pyridinamine (CAS: 5350-93-6) should be stored in a cool, dry place at temperatures below 25°C, away from light. It is best kept in a sealed, airtight container made of glass or high-density polyethylene (HDPE) to prevent moisture absorption and degradation. Avoid exposure to humid environments, and ensure storage areas are well-ventilated to maintain stability and safety.