Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate

Basic Information

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CAS Number

52373-72-5

Molecular Formula

C7H12O4

Molecular Weight

160.17 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

70-75 °C/10 mmHg

Density

1.106 g/mL at 25 °C

Refractive Index

n20/D 1.426(lit.)

SMILES

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CC1(OCC(O1)C(=O)OC)C

InChI

InChI=1S/C7H12O4/c1-7(2)10-4-5(11-7)6(8)9-3/h5H,4H2,1-3H3/t5-/m1/s1

InChIKey

DOWWCCDWPKGNGX-RXMQYKEDSA-N

LogP

0.31089999999999973

Topological Polar Surface Area

44.760000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

164

Safety Information

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GHS Hazard Pictograms

H227

Hazard Statement

H227 Combustible liquid
Flammable liquids

Synonyms & References

English

52373-72-5
Methyl(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylate
AS-15057
AMY31947
InChI=1/C7H12O4/c1-7(2)10-4-5(11-7)6(8)9-3/h5H,4H2,1-3H3/t5-/m1/s1
EN300-7366349
Methyl .alpha.,.beta.-isopropylidene-D-glycerate
1,3-Dioxolane-4-carboxylic acid, 2,2-dimethyl-, methyl ester, (R)-
1,3-Dioxolane-4-carboxylic acid, 2,2-dimethyl-, methyl ester, (4R)-
methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate
Methyl (R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate
(R)-(+)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic Acid Methyl Ester
Methyl 2,3-O-isopropylidene-D-glycerate
A7683
SCHEMBL877770
CS-W008189
Methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate, 98%
J-521715
(R)-(+)-2,2-dimethyl-1,3-dioxolan-4-carboxylic acid methyl ester
(R)-2,2-Dimethyl-1,3-dioxolan-4-carboxylic acid methyl ester
(R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid methyl ester
MFCD00066527
(R)-2,2-Dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester
D2562
(R)-methyl2,2-dimethyl-1,3-dioxolane-4-carboxylate
BCP05163
AKOS015842237
DTXSID00357405
(+)-2,3-O-Isopropylidene-D-glyceric Acid Methyl Ester
Methyl (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-carboxylate
AKOS015910913

MDL Number

MFCD00066527

Customs Code

2932999099

FAQ

What are the physical and chemical properties of Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (CAS: 52373-72-5)?

Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate is a white crystalline solid with a molecular weight of approximately 144.14 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is reactive towards nucleophiles and can undergo esterification and nucleophilic substitutions. It has a melting point of around 58-59°C and a boiling point of about 130-135°C at 10 mmHg.

How is Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (CAS: 52373-72-5) typically synthesized?

Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate can be synthesized via the esterification of (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylic acid with methyl alcohol. Commonly, a mineral acid like sulfuric acid is used as a catalyst. This method provides a high yield with good selectivity, ensuring that the desired (4R) configuration is maintained.

What industries use Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (CAS: 52373-72-5)?

Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate finds applications in various industries, including pharmaceuticals, where it is used as an intermediate for the synthesis of drugs. It is also utilized in the production of polymers and in the manufacture of sensors and semiconductors due to its chemical reactivity and stability.

What precautions should be taken when handling Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate (CAS: 52373-72-5)?

When handling Methyl (4R)-2,2-dimethyl-1,3-dioxolane-4-carboxylate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. This compound should be managed in a well-ventilated area, preferably a fume hood, to avoid inhalation of harmful vapors. Spills should be immediately cleaned up with absorbent material and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.