2-Chloro-5-pyrimidinol

Basic Information

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CAS Number

4983-28-2

Molecular Formula

C4H3ClN2O

Molecular Weight

130.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

190-195°C

Boiling Point

328.1℃ at 760 mmHg

Refractive Index

1.59

SMILES

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C1=C(C=NC(=N1)Cl)O

InChI

InChI=1S/C4H3ClN2O/c5-4-6-1-3(8)2-7-4/h1-2,8H

InChIKey

BOGPIHXNWPTGNH-UHFFFAOYSA-N

LogP

0.8355999999999999

Topological Polar Surface Area

46.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

72.4

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

BCP22868
GS-5821
MFCD09743796
BP-21031
C3685
AM20100217
5-PYRIMIDINOL, 2-CHLORO-
SCHEMBL130940
SY008717
A7410
PB12674
2-chloro-5-pyrimidinol
BCP9000103
EN300-113777
2-Chloro-5-pyrimidinol; 2-Chloropyrimidin-5-ol
CS-W004687
2-CHLOROPYRIMIDIN-5-OL
FT-0650126
Q-102842
AKOS006331670
2-Chloro-5-hydroxypyrimidine
A827868
DTXSID50562027
4983-28-2
BOGPIHXNWPTGNH-UHFFFAOYSA-N
2-chloranylpyrimidin-5-ol
2-chloropyrimidin-5-ol

MDL Number

MFCD09743796

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 2-Chloro-5-pyrimidinol (CAS: 4983-28-2)?

2-Chloro-5-pyrimidinol (CAS: 4983-28-2) is a crystalline compound with a molecular weight of approximately 143.58 g/mol. It has a solubility of about 1.2 g/L in water and can be reactive under certain conditions. This compound is known for its stability in solid form but requires careful handling due to its chemical reactivity.

How is 2-Chloro-5-pyrimidinol (CAS: 4983-28-2) typically synthesized?

2-Chloro-5-pyrimidinol (CAS: 4983-28-2) is commonly synthesized through a multi-step process involving pyrimidine chlorination and subsequent hydrolysis. This synthesis often employs reagents like thionyl chloride and is conducted under anhydrous conditions to achieve high yield and selectivity.

What industries use 2-Chloro-5-pyrimidinol (CAS: 4983-28-2)?

2-Chloro-5-pyrimidinol (CAS: 4983-28-2) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the polymer industry for enhancing material properties and in the sensor industry for developing chemical detection devices.

What precautions should be taken when handling 2-Chloro-5-pyrimidinol (CAS: 4983-28-2)?

When handling 2-Chloro-5-pyrimidinol (CAS: 4983-28-2), it is crucial to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Storage should be in a cool, dry place, away from moisture and heat sources. Fume hoods should be used during handling to minimize inhalation risk. Always consult the Safety Data Sheet (SDS) for detailed guidance on proper handling and disposal.