Tetrahydro-3-furanol

Basic Information

View in Editor

CAS Number

453-20-3

Molecular Formula

C4H8O2

Molecular Weight

88.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

25°C

Boiling Point

181 °C

Refractive Index

n20/D 1.45(lit.)

Vapor Pressure

760 mmHg ( 181 °C)

SMILES

View in Editor

C1COCC1O

InChI

InChI=1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2

InChIKey

XDPCNPCKDGQBAN-UHFFFAOYSA-N

LogP

-0.23239999999999994

Topological Polar Surface Area

29.46 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

44.8

Safety Information

View Safety Information

GHS Hazard Pictograms

H319

Hazard Statement

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Stability

Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

Synonyms & References

English

W-106142
DTXSID20868947
SY016904
(+/-)-3-hydroxytetrahydrofuran
3-Hydroxytetrahydrofuran, Vetec(TM) reagent grade, 98%
453-20-3
FT-0670164
oxolan-3-ol
S-3-Hydroxytetrahydrofuran
EINECS 207-219-2
BRN 0102545
Q4634149
F0001-1228
Tetrahydrofuran, 3-hydroxy-
PB25950
NS00001466
AI3-28120
3-hydroxytetrahydofuran
3-tetrahydrofuranol
PB17096
3-hydroxy tetrahydrofuran
3-hydroxytetrahydrofurane
SY003288
Tetrahydro-3-furanol
84976-47-6
H1331
MFCD00005374
5-17-03-00064 (Beilstein Handbook Reference)
rac-3-hydroxy-tetrahydrofuran
3-Hydroxytetrahydrofuran, ReagentPlus(R), 98%
AKOS009157141

MDL Number

MFCD00005374

FAQ

What are the physical and chemical properties of Tetrahydro-3-furanol (CAS: 453-20-3)?

Tetrahydro-3-furanol (CAS: 453-20-3) is a colorless to light yellow liquid with a distinctive odor. The molecular weight is 92.11 g/mol. It is slightly soluble in water but highly soluble in ethanol and ether. Tetrahydro-3-furanol is moderately reactive, particularly towards oxidizing agents. It has a boiling point of 118°C and a melting point of -85°C. This compound is used in various applications due to its unique properties.

How is Tetrahydro-3-furanol (CAS: 453-20-3) typically synthesized?

Tetrahydro-3-furanol (CAS: 453-20-3) is synthesized via the reduction of 3-furancarboxylic acid. Common methods include catalytic hydrogenation using platinum-based catalysts under pressure. The reaction is carried out in the presence of an inert solvent at temperatures around 50-60°C. The yield is typically high, and the selectivity is favorable for the formation of the desired tetrahydro-3-furanol product.

What industries use Tetrahydro-3-furanol (CAS: 453-20-3)?

Tetrahydro-3-furanol (CAS: 453-20-3) is widely used in the pharmaceutical industry for drug intermediates and in the polymer industry for enhancing the performance of certain materials. It is also utilized in the manufacturing of organic electronic materials, particularly in semiconductors, and as a fragrance and flavor component in the cosmetic and food industries.

What precautions should be taken when handling Tetrahydro-3-furanol (CAS: 453-20-3)?

When handling Tetrahydro-3-furanol (CAS: 453-20-3), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. This compound should be handled in a well-ventilated area or under a fume hood. Always refer to the Safety Data Sheet (SDS) for detailed information on storage, disposal, and emergency procedures. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly ventilated.