Azathioprine | CAS No. 446-86-6

Q: What is Azathioprine (CAS: 446-86-6)?

Azathioprine (CAS: 446-86-6) is an immunosuppressive drug used primarily to prevent organ rejection after transplantation. Its chemical formula is C10H11N5O5S, and it is a white to off-white crystalline powder with low solubility in water. It is known for its ability to inhibit DNA synthesis and is commonly used in the treatment of autoimmune diseases and inflammatory conditions.

Q: What are the main uses of Azathioprine (CAS: 446-86-6)?

Azathioprine (CAS: 446-86-6) is mainly used in immunosuppression therapy, including preventing organ rejection in transplant patients, treating conditions like rheumatoid arthritis, lupus, and inflammatory bowel disease. It is also used in research for studying immune system modulation and in veterinary medicine for managing certain immune-related disorders.

Q: Is Azathioprine (CAS: 446-86-6) safe?

Azathioprine (CAS: 446-86-6) is generally safe when used under medical supervision. However, it can cause side effects such as bone marrow suppression, liver toxicity, and increased risk of infections. Proper handling and adherence to safety guidelines are essential to minimize risks. It is classified as a prescription medication with specific safety standards in place.

Q: How should Azathioprine (CAS: 446-86-6) be stored?

Azathioprine (CAS: 446-86-6) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to prevent moisture absorption. The recommended storage temperature is between 15°C and 30°C (59°F and 86°F), and it should be protected from light to maintain stability and effectiveness.

Azathioprine

Basic Information

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CAS Number

446-86-6

Molecular Formula

C9H7N7O2S

Molecular Weight

277.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Physical State

Powder

Melting Point

244°C(dec.)

Boiling Point

555.8°C at 760 mmHg

Water Solubility

<0.1 g/100 mL at 23 ºC

Flash Point

685.7 °C at 760 mmHg

Solubility

Soluble in Dichloromethane and dimethyl sulfoxide.

Refractive Index

1.7400 (estimate)

SMILES

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CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]

InChI

InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)

InChIKey

LMEKQMALGUDUQG-UHFFFAOYSA-N

LogP

log Kow = 0.10

pKa

8.2(at 25℃)

Complexity

354

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H350 May cause cancer
Carcinogenicity

Hazard Class

Class IRRITANT Class IRRITANT

Stability

Stable. Incompatible with strong oxidizing agents, strong bases.

Synonyms & References

English

NCGC00015060-05
AZATHIOPRINE [USP MONOGRAPH]
Z57063156
HMS2091K19
Azathiopurine,(S)
6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine
Azasan
A 4638
NCGC00015060-07
AZATHIOPRINE (EP MONOGRAPH)
DivK1c_000586
Azathioprinum
Azathioprine, meets USP testing specifications
6-(Methyl-p-nitro-5-imidazolyl)-thiopurine
AZATHIOPRINE [MI]
CCG-39877
6-(1-methyl-4-nitro-1H-imidazol-5-ylthio)-9H-purine
HMS3260E15
DTXSID4020119
446-86-6
AB00443544_13
KBioGR_000646
azanine
NCGC00090836-02
6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine
HSDB 7084
AB00443544
AZATHIOPRINE (USP-RS)
KBioSS_000464
NC00614
6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine

MDL Number

MFCD00055974

Customs Code

2933990090

FAQ

What is Azathioprine (CAS: 446-86-6)?

Azathioprine (CAS: 446-86-6) is an immunosuppressive drug used primarily to prevent organ rejection after transplantation. Its chemical formula is C10H11N5O5S, and it is a white to off-white crystalline powder with low solubility in water. It is known for its ability to inhibit DNA synthesis and is commonly used in the treatment of autoimmune diseases and inflammatory conditions.

What are the main uses of Azathioprine (CAS: 446-86-6)?

Azathioprine (CAS: 446-86-6) is mainly used in immunosuppression therapy, including preventing organ rejection in transplant patients, treating conditions like rheumatoid arthritis, lupus, and inflammatory bowel disease. It is also used in research for studying immune system modulation and in veterinary medicine for managing certain immune-related disorders.

Is Azathioprine (CAS: 446-86-6) safe?

Azathioprine (CAS: 446-86-6) is generally safe when used under medical supervision. However, it can cause side effects such as bone marrow suppression, liver toxicity, and increased risk of infections. Proper handling and adherence to safety guidelines are essential to minimize risks. It is classified as a prescription medication with specific safety standards in place.

How should Azathioprine (CAS: 446-86-6) be stored?

Azathioprine (CAS: 446-86-6) should be stored in a cool, dry place away from direct light. It is typically kept in airtight containers to prevent moisture absorption. The recommended storage temperature is between 15°C and 30°C (59°F and 86°F), and it should be protected from light to maintain stability and effectiveness.