4,4',4''-Phosphoryltrimorpholine

Basic Information

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CAS Number

4441-12-7

Molecular Formula

C12H24N3O4P

Molecular Weight

305.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Basic Physical Properties

Melting Point

189.0 to 193.0 deg-C

Boiling Point

476.4℃ at 760 mmHg

Flash Point

241.9 °C

Refractive Index

1.5540 (estimate)

SMILES

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C1COCCN1P(=O)(N2CCOCC2)N3CCOCC3

InChI

InChI=1S/C12H24N3O4P/c16-20(13-1-7-17-8-2-13,14-3-9-18-10-4-14)15-5-11-19-12-6-15/h1-12H2

InChIKey

WXMQHPKQCPCDQO-UHFFFAOYSA-N

LogP

0.09110000000000129

Topological Polar Surface Area

54.480000000000004 Å²

Hydrogen Bond Donor/Acceptor

0 / 7

Complexity

300

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Trimorpholinophosphine oxide
TMPO
Tri(4-morpholino)phosphine oxide
2,4,6-Trihydroxybenzoic acid hydrate
4-dimorpholin-4-ylphosphorylmorpholine
Phosphoric acid trimorpholide
Phosphoric Trimorpholide
4,4',4''-phosphoryltrimorpholine
Tri(4-morpholinyl)phosphine oxide
TMPO;Tris-(morpholino)-phosphine oxide
4-[bis(morpholin-4-yl)phosphoroso]morpholine
NSC41250
5-n-Propylbenzoic Acid
KSC493M7L
C12H24N3O4P
trimorpholin-4-ylphosphino-1-one
WXMQHPKQCPCDQO-UHFFFAOYSA-N
Tris-(morpholino)-phosphine oxide
PHOSPHORIC ACIDTRIM

MDL Number

MFCD00047406

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 4,4',4''-Phosphoryltrimorpholine (CAS: 4441-12-7)?

4,4',4''-Phosphoryltrimorpholine is a white or off-white crystalline solid with a molecular weight of approximately 246.15 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. The compound is reactive towards nucleophiles and can undergo phosphonium ylide reactions. It is stable under normal storage conditions but should be protected from moisture and heat.

How is 4,4',4''-Phosphoryltrimorpholine (CAS: 4441-12-7) typically synthesized?

4,4',4''-Phosphoryltrimorpholine is synthesized by the phosphorylation of trimorpholine with phosphorus oxychloride in the presence of anhydrous conditions. The reaction is typically carried out at room temperature and yields up to 90% of the desired product. The catalyst and reagents are carefully selected to ensure high selectivity and yield.

What industries use 4,4',4''-Phosphoryltrimorpholine (CAS: 4441-12-7)?

4,4',4''-Phosphoryltrimorpholine is used in the pharmaceutical industry for the synthesis of certain drugs due to its unique chemical properties. It is also utilized in the polymer industry for the modification of polymers and in the sensor industry for the development of chemical sensors. Additionally, it has potential applications in semiconductor manufacturing for specific chemical treatments.

What precautions should be taken when handling 4,4',4''-Phosphoryltrimorpholine (CAS: 4441-12-7)?

4,4',4''-Phosphoryltrimorpholine should be handled in a well-ventilated area and under a fume hood. Personal protective equipment (PPE) including gloves, safety glasses, and a lab coat is required. Spills should be addressed immediately by using appropriate absorbents and disposing of waste according to local regulations. Detailed safety data sheets (SDS) should be consulted for specific handling and disposal procedures.