6-(Methylamino)purine

Basic Information

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CAS Number

443-72-1

Molecular Formula

C6H7N5

Molecular Weight

149.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

308°C

Boiling Point

492.9°C at 760 mmHg

Density

1.476

Flash Point

251.9°C

Refractive Index

1.792

SMILES

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CNC1=NC=NC2=C1NC=N2

InChI

InChI=1S/C6H7N5/c1-7-5-4-6(10-2-8-4)11-3-9-5/h2-3H,1H3,(H2,7,8,9,10,11)

InChIKey

CKOMXBHMKXXTNW-UHFFFAOYSA-N

LogP

0.39459999999999973

Topological Polar Surface Area

66.49000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

139

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

6-N-METHYLADENINE
6-Monomethylaminopurine
C08434
AKOS028112370
N(Sup6)-Methyladenine
NS00014882
DS-7790
NCGC00248494-01
(N-6)-Methyladenine
9H-PURIN-6-AMINE, N-METHYL-
NSC11580
NCGC00257570-01
N6 -methyl-adenine
1H-Purin-6-amine, N-methyl-
EN300-76775
NSC 11580
N-methyl-N-(9H-purin-6-yl)amine
MFCD00075820
N6M
methyl (9H-purin-6-yl)-amine
FT-0653186
6-Methylamino-9H-purine
CHEMBL1738843
SY112980
6-Methylaminopurine
Adenine, N-methyl-
DTXSID1020857
n6-methyl adenine
SCHEMBL21913
METHYLADENINE, (N-6)-
methyl-(9H-purin-6-yl)amine

MDL Number

MFCD00075820

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-(Methylamino)purine (CAS: 443-72-1)?

6-(Methylamino)purine is a white to off-white crystalline solid with a molecular weight of approximately 167.17 g/mol. It is slightly soluble in water and organic solvents. Chemically, it is stable under normal conditions but may react with strong oxidizing agents. It is used as a starting material in the synthesis of nucleosides and pharmaceuticals.

How is 6-(Methylamino)purine (CAS: 443-72-1) typically synthesized?

6-(Methylamino)purine can be synthesized via the Strecker synthesis, where aminoacetonitrile is reacted with formaldehyde and hydrocyanic acid, followed by treatment with sodium methoxide. Other methods involve the use of methylamine in the presence of purine, yielding the target compound with good selectivity and yield.

What industries use 6-(Methylamino)purine (CAS: 443-72-1)?

6-(Methylamino)purine is primarily used in the pharmaceutical industry as a precursor in the synthesis of nucleoside drugs. It is also of interest in biotechnology and research for its potential in developing new medical treatments and diagnostics.

What precautions should be taken when handling 6-(Methylamino)purine (CAS: 443-72-1)?

When handling 6-(Methylamino)purine, it is important to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. Work should be conducted in a fume hood. In case of a spill, evacuate the area and follow local safety guidelines for chemical spills. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.