Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate

Basic Information

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CAS Number

41337-81-9

Molecular Formula

C9H11NO3

Molecular Weight

181.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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CCOC(=O)C1=CC=CC(=N1)CO

InChI

InChI=1S/C9H11NO3/c1-2-13-9(12)8-5-3-4-7(6-11)10-8/h3-5,11H,2,6H2,1H3

InChIKey

CDFOARSBQKJGNL-UHFFFAOYSA-N

LogP

0.7505999999999999

Topological Polar Surface Area

59.42 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

172

Synonyms & References

English

Ethyl 6-(hydroxymethyl)picolinate
2-Pyridinecarboxylic acid 6-(hydroxymethyl)-ethyl ester
Ethyl 6-(hydroxymethyl)pyridine-2-carboxylate
6-(hydroxymethyl)-2-pyridinecarboxylic acid ethyl ester
6-hydroxymethyl-ethyl picolinic ester
6-Hydroxymethyl-pyridin-2-carbonsaeure ethylester
6-hydroxymethylpyridine-2-carboxylic acid ethyl ester
ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate

MDL Number

MFCD09750009

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate (CAS: 41337-81-9)?

Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate is a crystalline solid with a molecular weight of approximately 216.23 g/mol. It has a pKa of 8.9 and is slightly soluble in water. The compound displays moderate reactivity towards nucleophiles and is stable under normal conditions but should be stored away from strong acids and bases. Its solubility varies with temperature and solvent type.

How is Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate (CAS: 41337-81-9) typically synthesized?

Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate is commonly synthesized via reductive amination of 2-pyridinecarboxaldehyde with ethylamine in the presence of a reducing agent like sodium borohydride. The reaction is performed under mild conditions to ensure high selectivity and yield. Catalysts such as sodium hydroxide are also used to achieve optimal results.

What industries use Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate (CAS: 41337-81-9)?

Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate finds application in the pharmaceutical industry as a precursor in the synthesis of various drug candidates. It is also used in the polymer industry for the development of functional polymers with enhanced properties. Additionally, the compound is employed in the production of sensors and semiconductors for its unique chemical functionality.

What precautions should be taken when handling Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate (CAS: 41337-81-9)?

When handling Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with caution, using absorbent materials and disposing of the waste in accordance with local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety and handling instructions.