Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate(CAS: 41337-81-9)

Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate is a crystalline solid with a molecular weight of approximately 216.23 g/mol. It has a pKa of 8.9 and is slightly soluble in water. The compound displays moderate reactivity towards nucleophiles and is stable under normal conditions but should be stored away from strong acids and bases. Its solubility varies with temperature and solvent type.

Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate is commonly synthesized via reductive amination of 2-pyridinecarboxaldehyde with ethylamine in the presence of a reducing agent like sodium borohydride. The reaction is performed under mild conditions to ensure high selectivity and yield. Catalysts such as sodium hydroxide are also used to achieve optimal results.

Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate finds application in the pharmaceutical industry as a precursor in the synthesis of various drug candidates. It is also used in the polymer industry for the development of functional polymers with enhanced properties. Additionally, the compound is employed in the production of sensors and semiconductors for its unique chemical functionality.

When handling Ethyl 6-(hydroxymethyl)-2-pyridinecarboxylate, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work must be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be handled with caution, using absorbent materials and disposing of the waste in accordance with local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety and handling instructions.