Lithium diisopropylamide

Basic Information

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CAS Number

4111-54-0

Molecular Formula

C6H14LiN

Molecular Weight

107.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Hydrocarbons

Basic Physical Properties

Boiling Point

65 °C

SMILES

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[Li+].CC(C)[N-]C(C)C

InChI

InChI=1S/C6H14N.Li/c1-5(2)7-6(3)4;/h5-6H,1-4H3;/q-1;+1

InChIKey

ZCSHNCUQKCANBX-UHFFFAOYSA-N

LogP

1.56950

Complexity

37.8

Safety Information

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GHS Hazard Pictograms

H250

H260

H314

H361

Hazard Statement

H250 Catches fire spontaneously if exposed to air
Pyrophoric liquids; Pyrophoric solids

H260 In contact with water releases flammable gases which may ignite spontaneously
Substances And Mixtures Which, In Contact With Water, Emit Flammable Gases

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 4.2 Class 4.2

Sensitiveness

Air & Moisture Sensitive

Synonyms & References

English

Lithiodiisopropylamine; Lithium diisopropylamide; Lithium diisopropylamine
lithiodiisopropyl amine
lithium di-isoproylamide
Lithium diisopropylamide
lithium diisopropyl-amide
LiNiPr2
Lithium diisopropyl amide
DTXSID6063305
SCHEMBL1961
lithium N,N-diisopropyl amide
LiN(iPr)2
lithium di-i-propylamide
lithium di-iso-propylamide
2-Propanamine, N-(1-methylethyl)-, lithium salt (1:1)
Lithium diisopropylamide, 97%
4111-54-0
li thium diisopropylamide
lithium,di(propan-2-yl)azanide
C6H14LiN
lithium di-isopropylamide
diisopropylamine lithium salt
lithium N,N-diisopropylamide
L0171
NS00083040
Lithium di-isopropyl amide
Lithium N-(propan-2-yl)propan-2-aminide
lithiumdiisopropyl amide
lithiodiisopropylamine
AKOS009158845
Lithium diisopropylamide, 10 wt. % suspension in hexanes
iPr2NLi

MDL Number

MFCD00064449

Customs Code

2924199090

FAQ

What is Lithium diisopropylamide (CAS: 4111-54-0)?

Lithium diisopropylamide (CAS: 4111-54-0) is a strong organic base with the chemical formula C6H15LiN. It is commonly used in chemical reactions due to its high nucleophilicity and ability to deprotonate acidic substrates. This compound is typically a colorless liquid and is known for its reactivity in synthetic organic chemistry applications.

What are the main uses of Lithium diisopropylamide (CAS: 4111-54-0)?

Lithium diisopropylamide (CAS: 4111-54-0) is widely utilized in pharmaceuticals for synthesizing complex organic molecules, in industry for polymerization reactions, and in research as a key reagent in alkylation and deprotonation processes. Its applications also extend to organic synthesis where it acts as a strong base and nucleophile, facilitating reactions such as the formation of enolates and other intermediates.

Is Lithium diisopropylamide (CAS: 4111-54-0) safe?

Lithium diisopropylamide (CAS: 4111-54-0) requires caution due to its corrosive nature and potential to cause skin and eye irritation. Safety standards emphasize proper handling with protective equipment, such as gloves and goggles, and working in a well-ventilated area. It is classified as a hazardous chemical, so adherence to OSHA guidelines and avoiding inhalation or contact with moisture is critical.

How should Lithium diisopropylamide (CAS: 4111-54-0) be stored?

Lithium diisopropylamide (CAS: 4111-54-0) should be stored in a cool, dry, and dark place, ideally at 2-8°C, in airtight containers made of glass or stainless steel. It is sensitive to moisture and air, so maintaining low humidity and keeping it sealed is essential. Storage precautions include avoiding exposure to light and ensuring it is kept away from incompatible materials to preserve stability.