2',3',5'-Tri-O-acetyluridine

Basic Information

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CAS Number

4105-38-8

Molecular Formula

C15H18N2O9

Molecular Weight

370.31 g/mol

EINECS

223-881-5

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

Off-White

Melting Point

127.0 to 131.0 °C

Boiling Point

No data available

Density

1.43±0.1 g/cm3(Predicted)

Flash Point

No data available

Solubility

Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly)

Refractive Index

1.552

SMILES

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CC(=O)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C

InChI

InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1

InChIKey

AUFUWRKPQLGTGF-FMKGYKFTSA-N

LogP

-1.13950

pKa

9.39±0.10(Predicted)

Complexity

660

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

CHEBI:90914
RG2133
Uridine triacetate (USAN/INN)
NS00047457
uridine-triacetate
PN401
RG 2133
2',3',5'-Triacetyluridine
[(2R,3R,4R,5R)-3,4-bis(acetyloxy)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl acetate
Q22075857
DTXSID40961409
D09985
Uridine triacetate
Uridine 2',3',5'-triacetate;2',3',5'-Triacetyluridine
CHEMBL2107381
PN-401
HY-14905
SY004945
MFCD00023795
s6484
Tri-O-acetyluridine
PN 401
Uridine, 2,3,5-triacetate
NSC788948
(2R,3R,4R,5R)-2-(ACETOXYMETHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)TETRAHYDROFURAN-3,4-DIYL DIACETATE
NSC-788948
2 inverted exclamation mark ,3 inverted exclamation mark ,5 inverted exclamation mark -Triacetyluridine
Uridine triacetate [USAN:INN]
CS-D1799
UNII-2WP61F175M
[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

MDL Number

MFCD00023795

EC Number

223-881-5

Customs Code

29349990

FAQ

What is 2',3',5'-Tri-O-acetyluridine (CAS: 4105-38-8)?

2',3',5'-Tri-O-acetyluridine is a modified form of uridine with three acetyl groups attached to the 2', 3', and 5' positions of the ribose sugar. It is used in various biochemical and pharmaceutical applications due to its stability and enhanced solubility. The chemical formula is C12H21NO7.

What are the main uses of 2',3',5'-Tri-O-acetyluridine (CAS: 4105-38-8)?

2',3',5'-Tri-O-acetyluridine is primarily used in pharmaceutical research, particularly in the development of antiviral drugs. It also serves as a reagent in nucleic acid synthesis and as a component in certain nucleoside analogues for therapeutic applications.

Is 2',3',5'-Tri-O-acetyluridine (CAS: 4105-38-8) safe?

2',3',5'-Tri-O-acetyluridine is generally considered safe for laboratory use, but handling should be done with care. Prolonged skin contact or inhalation of dust should be avoided. Protective gloves and goggles are recommended to minimize exposure risks.

How should 2',3',5'-Tri-O-acetyluridine (CAS: 4105-38-8) be stored?

2',3',5'-Tri-O-acetyluridine should be stored in a cool, dry place away from direct sunlight and moisture. It should be kept in a tightly sealed container to prevent degradation. The optimal storage temperature is below 20°C and the relative humidity should be kept below 60% to ensure stability.