1-Methoxy-4-(trifluoromethyl)benzene

Basic Information

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CAS Number

402-52-8

Molecular Formula

C8H7F3O

Molecular Weight

176.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

-9℃

Boiling Point

166.4℃ at 760 mmHg

Flash Point

60°(140°F)

Refractive Index

1.4450

SMILES

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COC1=CC=C(C=C1)C(F)(F)F

InChI

InChI=1S/C8H7F3O/c1-12-7-4-2-6(3-5-7)8(9,10)11/h2-5H,1H3

InChIKey

CFIPQRIPCRRISV-UHFFFAOYSA-N

LogP

2.7140000000000004

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

136

Safety Information

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Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Synonyms & References

English

4-(Trifluoromethyl)anisole
1-methoxy-4-(trifluoromethyl)benzene
SCHEMBL9876731
CS-W003005
SCHEMBL255255
Methyl 4-(trifluoromethyl)phenyl ether #
DTXSID10344942
4-Trifluoromethylanisole
FT-0632094
SY023182
1-(Trifluoromethyl)-4-methoxybenzene;1-Methoxy-4-(trifluoromethyl)benzene;4-Methoxybenzotrifluoride
4-trifluoromethyl-anisol
MFCD03094456
AC-3821
p-trifluoromethylanisole
BXPKTSZAXXXEJB-UHFFFAOYSA-N
1-methoxy-4-trifluoromethyl-benzene
PS-8587
402-52-8
VFWITSIASOVRGA-UHFFFAOYSA-N
A19878
4-METHOXYBENZOTRIFLUORIDE
AKOS006227739
AM61517
Benzene, 1-methoxy-4-(trifluoromethyl)-
J-513912
1-Methoxy-4-(trifluoromethyl)benzene
4-Methoxybenzotrifluoride
Anisole,p-(trifluoromethyl)- (7CI,8CI)
4-Methoxy-1-(trifluoromethyl)benzene
Methylp-trifluoromethylphenyl ether

MDL Number

MFCD03094456

Customs Code

2909309090

FAQ

What regulatory guidelines apply to 1-Methoxy-4-(trifluoromethyl)benzene (CAS: 402-52-8)?

1-Methoxy-4-(trifluoromethyl)benzene (CAS: 402-52-8) is subject to various regulatory guidelines including GHS classification, REACH regulations, and FDA/EPA requirements. GHS classifies it as a hazardous substance due to its flammability and potential for skin irritation. REACH requires manufacturers and importers to register the substance if produced or imported in quantities above 1 ton per year. FDA and EPA have specific regulations for the handling and disposal of this compound to protect human health and the environment.

Are there alternatives to 1-Methoxy-4-(trifluoromethyl)benzene in synthesis?

Alternative reagents to 1-Methoxy-4-(trifluoromethyl)benzene include other substituted benzenes and fluoroanilines. For instance, p-tolualdehyde can be used as an alternative for alkylation reactions. Isomers such as 4-Methoxy-1-(trifluoromethyl)benzene are also available. These alternatives offer similar reactivity but may differ in solubility and ease of purification.

What is the market or research trend for 1-Methoxy-4-(trifluoromethyl)benzene (CAS: 402-52-8)?

The market for 1-Methoxy-4-(trifluoromethyl)benzene (CAS: 402-52-8) is driven by its use in pharmaceuticals, electronics, and as a precursor in organic synthesis. Research trends focus on its application in developing new drugs and as a functional material in electronics. Recent studies indicate increasing demand due to its unique properties, such as high thermal stability and low volatility. However, there is also a growing interest in sustainable alternatives and safer handling practices.

How should waste containing 1-Methoxy-4-(trifluoromethyl)benzene (CAS: 402-52-8) be handled?

Waste containing 1-Methoxy-4-(trifluoromethyl)benzene (CAS: 402-52-8) should be collected in sealed, leak-proof containers and stored away from sources of ignition. Incineration or professional waste disposal services are recommended for safe disposal. Environmental protection precautions include ensuring that the waste does not contaminate soil or water. Compliance with local and international environmental regulations is essential to prevent environmental harm. Additionally, proper training and personal protective equipment (PPE) should be used during handling and disposal to ensure safety.