2-Furyl(1-piperazinyl)methanone

Basic Information

View in Editor

CAS Number

40172-95-0

Molecular Formula

C9H12N2O2

Molecular Weight

180.21 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

67-70 °C

Boiling Point

137-140°C 0,1mm

Flash Point

>230 °F

Refractive Index

1.5373 (estimate)

SMILES

View in Editor

C1CN(CCN1)C(=O)C2=CC=CO2

InChI

InChI=1S/C9H12N2O2/c12-9(8-2-1-7-13-8)11-5-3-10-4-6-11/h1-2,7,10H,3-6H2

InChIKey

SADPINFEWFPMEA-UHFFFAOYSA-N

LogP

0.32499999999999996

Topological Polar Surface Area

45.480000000000004 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

190

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Hygroscopic

Synonyms & References

English

W-106385
1-(furan-2-yl-methanoyl)piperazine
n-(2-furoyl)piperazine
ChemDiv2_000230
SR-01000391623
1-PENTANONMETHANONE, 2-FURANYL-1-PIPERAZINYL-
Terazosin impurity L, European Pharmacopoeia (EP) Reference Standard
1-(Furan-2-ylcarbonyl)piperazine
furoylpiperazine
MFCD00038831
Terazosin Impurity L
1-(2-Furoyl)-piperazine
DTXSID7057735
N-(FURAN-2-OYL)PIPERAZINE
SB61034
CHEMBL3560648
EN300-19815
1-(2-Furoyl)piperazine
8AUX72LL1P
UNII-8AUX72LL1P
2-Furoic piperazide
AK-968/40153077
1-(2-furylcarbonyl)piperazine
TERAZOSIN HYDROCHLORIDE DIHYDRATE IMPURITY L [EP IMPURITY]
SDCCGMLS-0065725.P001
N-furoyl piperazine
DTXCID8031524
BP-13003
Tox21_113787
Piperazine, 1-(2-furanylcarbonyl)-
(furan-2-yl)(piperazin-1-yl)methanone

MDL Number

MFCD00038831

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-Furyl(1-piperazinyl)methanone (CAS: 40172-95-0)?

2-Furyl(1-piperazinyl)methanone is a white solid with a molecular weight of approximately 217.21 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and ethanol. The compound is moderately reactive, showing basic characteristics due to the piperazine group. It can undergo nucleophilic substitution and condensation reactions.

How is 2-Furyl(1-piperazinyl)methanone (CAS: 40172-95-0) typically synthesized?

2-Furyl(1-piperazinyl)methanone is typically synthesized by the reaction of 2-furylamine with piperazine in the presence of an acid catalyst such as trifluoroacetic acid. The process involves a condensation reaction followed by a deprotonation step. The yield is generally around 70-80%, and the product can be purified by recrystallization from ethanol.

What industries use 2-Furyl(1-piperazinyl)methanone (CAS: 40172-95-0)?

2-Furyl(1-piperazinyl)methanone finds applications in the pharmaceutical industry as an intermediate in drug synthesis. It is also used in the chemical industry for the development of new materials and in the synthesis of certain types of polymers. Additionally, it has potential uses in the sensor and semiconductor industries due to its molecular structure and reactivity.

What precautions should be taken when handling 2-Furyl(1-piperazinyl)methanone (CAS: 40172-95-0)?

When handling 2-Furyl(1-piperazinyl)methanone, appropriate personal protective equipment (PPE) such as gloves and safety goggles should be worn. It should be stored in a cool, dry area away from direct sunlight and flammable materials. Handling should be done in a well-ventilated area or within a fume hood to avoid inhalation of dust or vapors. In case of spill, use appropriate cleaning agents and follow a spill kit protocol. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines.