Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (1:1)

Basic Information

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CAS Number

40126-30-5

Molecular Formula

C6H12ClNO3

Molecular Weight

181.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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COC(=O)C1CC(CN1)O.Cl

InChI

InChI=1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5-;/m0./s1

InChIKey

KLGSHNXEUZOKHH-FHAQVOQBSA-N

LogP

-0.6960000000000002

Topological Polar Surface Area

58.56 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

137

Synonyms & References

English

(cis)-4-Hydroxy-L-proline, methyl ester hydrochloride
Methyl cis-4-Hydroxy-L-proline Hydrochloride
CS-W017145
40126-30-5
MFCD00237835
cis-4-Hydroxy-L-proline methyl ester hydrochloride
H-Cis-Hyp-Ome HCl
H-cis-Hyp-OMe (hydrochloride)
L-Proline, 4-hydroxy-, methyl ester, hydrochloride, (4S)-
Cis-4-hydroxy-L-proline methyl ester, HCl
KLGSHNXEUZOKHH-FHAQVOQBSA-N
H-cis-Hyp-Ome.HCl
SCHEMBL135153
CS-11422
HY-W016429
Methyl (4S)-4-hydroxy-L-prolinate--hydrogen chloride (1/1)
Methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate hydrochloride
methyl (2S,4S)-4-hydroxypyrrolidine-2-carboxylate;hydrochloride
cis-L-4-Hydroxyproline methyl ester hydrochloride
cis-4-hydroxyproline methyl ester HCl salt
Q-102758
AMY4460
227935-34-4
EN300-108342
AC-26247
(2S,4S)-4-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride
AKOS016842313
cis-4-Hydroxy-L-proline methyl ester HCl
(2s,4s)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
DTXSID10509291
EN300-250724

MDL Number

MFCD00237835

FAQ

What are the physical and chemical properties of Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5)?

Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5) is a white crystalline powder with a molecular weight of approximately 246.2 g/mol. It has good solubility in water and alcohol. This compound is less reactive under normal conditions but shows moderate acidity due to the presence of the hydrochloride group. It is stable in dry conditions but should be stored in a sealed container to prevent hydrolysis and degradation.

How is Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5) typically synthesized?

Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5) can be synthesized through the condensation of (S)-4-hydroxy-L-proline with methylamine followed by protonation with hydrochloric acid. Commonly, this process involves the use of a mild acid catalyst and debenzylation steps to achieve the desired product with high selectivity and yield.

What industries use Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5)?

Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in the polymer industry for the modification of polymer properties, and in the sensor industry for developing biosensors. Additionally, it has applications in the semiconductor industry for surface modification and as a reagent in chemical synthesis.

What precautions should be taken when handling Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5)?

When handling Methyl (4S)-4-hydroxy-L-prolinate hydrochloride (CAS: 40126-30-5), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry, and well-ventilated area. It should be used in a fume hood to minimize exposure. In case of spills, they should be cleaned up promptly with absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.