1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine

Basic Information

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CAS Number

387350-39-2

Molecular Formula

C7H7F3N2

Molecular Weight

176.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

62-64℃/0.5mm

Density

1.293

Flash Point

79.2℃

Refractive Index

1.466

SMILES

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C1=CC(=NC=C1CN)C(F)(F)F

InChI

InChI=1S/C7H7F3N2/c8-7(9,10)6-2-1-5(3-11)4-12-6/h1-2,4H,3,11H2

InChIKey

XPXVAYGVYBQKDE-UHFFFAOYSA-N

LogP

1.5591

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

146

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AKOS006230000
[6-(trifluoromethyl)pyridin-3-yl]methylamine
SCHEMBL40545
([6-(trifluoromethyl)pyridin-3-yl]methyl)amine
A824249
C-(6-trifluoromethyl-pyridin-3-yl)-methylamine
CS-W006446
6-trifluoromethylpyrid-3-ylmethyl amine
EN300-260999
MFCD01862649
JWEGHQTVRVABAH-UHFFFAOYSA-N
[6-(trifluoromethyl)pyridin-3-yl]methanamine
[6-(trifluoromethyl)pyridin-3- yl]methylamine
J-501641
3-Aminomethyl-6-(trifluoromethyl)pyridine, AldrichCPR
5-(aminomethyl)-2-(trifluoromethyl)pyridine
1-[6-(trifluoromethyl)pyridin-3-yl]methanamine
3-aminomethyl-6-trifluoromethylpyridine
[6-(trifluoromethyl)-3-pyridinyl]methanamine
3-Aminomethyl-6-(trifluoromethyl)pyridine
3-aminomethyl-6-trifluoromethyl pyridine
SY009409
AMY3031
FT-0647096
(6-(trifluoromethyl)pyridin-3-yl)methanamine
387350-39-2
DTXSID10372225
5-aminomethyl-2-trifluoromethyl pyridine
5-aminomethyl-2-(trifluoromethyl)pyridine
C7H7F3N2
FS-1196

MDL Number

MFCD01862649

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine (CAS: 387350-39-2)?

1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine is a crystalline compound with a molecular weight of approximately 247.13 g/mol. It is slightly soluble in water and has good solubility in organic solvents like methanol and acetone. It exhibits basic reactivity due to the amine group and can undergo nucleophilic substitution reactions. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is 1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine (CAS: 387350-39-2) typically synthesized?

1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine is synthesized via a multi-step process involving the reaction of 6-(trifluoromethyl)pyridine with a primary amine. The synthesis often requires the use of a suitable catalyst and can be optimized to achieve high yields. The final product is typically isolated and purified using chromatographic techniques.

What industries use 1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine (CAS: 387350-39-2)?

1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine is primarily used in the pharmaceutical industry for the synthesis of certain drug molecules. It also finds applications in the polymer industry for the development of functional materials. Additionally, it can be used in semiconductors for doping purposes and in sensors for its unique chemical reactivity.

What precautions should be taken when handling 1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine (CAS: 387350-39-2)?

When handling 1-[6-(Trifluoromethyl)-3-pyridinyl]methanamine, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate disposal methods as outlined in the safety data sheet (SDS). Storage should be in a cool, dry place away from direct sunlight and flammable materials.