(11beta,16alpha,17alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid | CAS No. 37927-01-8

(11beta,16alpha,17alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid

Basic Information

CAS Number

37927-01-8

Molecular Formula

C21H27FO5

Molecular Weight

378.44 g/mol

AD

Basic Physical Properties

Melting Point

274-2770C

CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)O)O)C)O)F)C

InChI

InChI=1S/C21H27FO5/c1-11-8-15-14-5-4-12-9-13(23)6-7-18(12,2)20(14,22)16(24)10-19(15,3)21(11,27)17(25)26/h6-7,9,11,14-16,24,27H,4-5,8,10H2,1-3H3,(H,25,26)/t11-,14+,15+,16+,18+,19+,20+,21+/m1/s1

InChIKey

PFAGPIFFRLDBRN-AFKBWYBQSA-N

LogP

2.4189000000000003

Topological Polar Surface Area

94.83000000000001 Ų

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

789

Synonyms & References

English

  • 9-Fluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylic Acid
  • DEXAMETHASONE SODIUM PHOSPHATE IMPURITY G [EP IMPURITY]
  • W19714
  • (-)-Dexamethasone Acid
  • UNII-BP8U81ZN41
  • ANDROSTA-1,4-DIENE-17-CARBOXYLIC ACID, 9-FLUORO-11,17-DIHYDROXY-16-METHYL-3-OXO-, (11.BETA.,16.ALPHA.,17.ALPHA.)-
  • 9-FLUORO-11.BETA.,17-DIHYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIENE-17.BETA.-CARBOXYLIC ACID
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylic acid
  • FLUOROANDROSTADIENE CARBOXYLIC ACID [USP IMPURITY]
  • (11beta,16alpha,17alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid
  • Dexamethasone sodium phosphate impurity G [EP]
  • AS-73559
  • 37927-01-8
  • (11?,16?,17?)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid
  • Dexamethasone Sodium phosphate Impurity G ((-)-Dexamethasone Acid)
  • Dexamethasone acid
  • Betamethasone acid, (-)-
  • DTXSID80512171
  • SCHEMBL1115827
  • (1R,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1-carboxylic acid
  • 9-Fluoro-11beta,17-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carboxylic acid
  • AKOS030242030
  • BP8U81ZN41
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-FLUORO-11,17-DIHYDROXY-10,13,16-TRIMETHYL-3-OXO-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-3H-CYCLOPENTA[A]PHENANTHRENE-17-CARBOXYLIC ACID
  • 9-Fluoro-11?,17-dihydroxy-16?-methyl-3-oxoandrosta -1,4-diene-17?-carboxylic Acid
  • Androsta-1,4-diene-17-carboxylic acid, 9-fluoro-11,17-dihydroxy-16-methyl-3-oxo-, (11beta,16alpha,17alpha)-
  • 9-Fluoro-11,17-dihydroxy-16a-methyl-3-oxoandrosta-1,4-diene-17-carboxylic Acid
  • (11?,16?,17?)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid; (-)-Dexamethasone acid; 9-Fluoro-11?,17-dihydroxy-16?-methyl-3-oxoandrosta-1,4-diene-17?-carboxylic acid; Dexamethasone Sodium Phosphate Imp. G (EP); Dexamethasone Sodium Phosphate Impurity G; Dexamethasone Phosphate Impurity G
  • Androsta-1,4-diene-17-carboxylicacid, 9-fluoro-11,17-dihydroxy-16-methyl-3-oxo-, (11b,16a,17a)-
  • Dexamethasone Acid
  • (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic acid

MDL Number

MFCD12031457

FAQ

What regulatory guidelines apply to (11beta,16alpha,17alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid (CAS: 37927-01-8)?

This compound is subject to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), REACH regulations in the EU, and FDA/EPA requirements in the USA. Manufacturers and importers must ensure proper hazard communication, provide safety data sheets, and comply with classification and labeling rules.

Are there alternatives to (11beta,16alpha,17alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid in synthesis?

Alternatives such as other steroid hormones or synthetic analogs may be used. For instance, 17α-hydroxyandrost-4-en-3-one or other fluoro-substituted steroids can serve as synthetic alternatives depending on the specific application and desired properties.

What is the market or research trend for (11beta,16alpha,17alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid?

The research trend for this compound is focused on its potential as a precursor or intermediate in steroid synthesis, with increasing interest in its use in pharmaceutical and chemical industries. Market analysis indicates growing demand for specialized intermediates in drug development.

How should waste containing (11beta,16alpha,17alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carboxylic acid be handled?

Waste containing this compound should be collected in appropriate containers and handled under safe conditions. Disposal should follow local regulations, often requiring incineration or professional waste disposal services to ensure environmental safety and compliance with hazardous waste management standards.

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