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(8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol | CAS No. 37115-43-8

(8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol

Basic Information

Chemical_Structure_Of
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CAS Number

37115-43-8

Molecular Formula

C17H13ClN4O

Molecular Weight

324.77 g/mol

AD

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds
Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates
Fine Chemicals Dyes and Pigments Organic Dyes
Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

129-134°C

Boiling Point

556.1 °C at 760 mmHg

Density

1.45

Solubility

methylene chloride: ~20 mg/mL, clear, colorless to faintly yellow

Refractive Index

1.729

SMILES

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C1C2=NN=C(N2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4)CO

InChI

InChI=1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2

InChIKey

ZURUZYHEEMDQBU-UHFFFAOYSA-N

LogP

2.764000000000001

Topological Polar Surface Area

63.300000000000004 Ų

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

454

Safety Information

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Hazard Statement

H225 Highly Flammable liquid and vapor
Flammable liquids
H370 Causes damage to organs
Specific target organ toxicity, single exposure

Synonyms & References

English

  • AKOS030242019
  • ?-hydroxy Alprazolam
  • 6-phenyl-8-chloro-4H-s-triazolo [4,3-a][1,4]benzodiazepine-1-methanol
  • Alprazolam-M alpha-Hydroxy
  • alpha-Hydroxyalprazolam
  • V7J2Z5Y50U
  • CHEBI:192657
  • 8-chloro-1-(hydroxymethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
  • alpha-Hydroxyalprazolam; -[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-1-methanol, 8-chloro-6-phenyl-; 1-Hydroxyalprazolam; 1'-Hydroxyalprazolam; 6-Phenyl-8-chloro-4H-s-triazolo[4,3-a]benzodiazepine-1-methanol; U 40125
  • Alpha-Hydroxyalprazolam, 0.1mg/ml in Methanol
  • cp.
  • .ALPHA.-HYDROXYALPRAZOLAM
  • CHEMBL3246317
  • 8-CHLORO-6-PHENYL-4H-(1,2,4)TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE-1-METHANOL
  • alpha-Hydroxyalprazolam 0.1 mg/ml in Methanol
  • {12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaen-3-yl}methanol
  • .alpha.-hydroxy-alprazolam
  • 6-phenyl-8-chloro-4-H-s-triazolo[4,3-a][1,4]benzodiazepine-1-methanol
  • 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine-1-methanol, 8-chloro-6-phenyl-
  • alpha-Hydroxyalprazolam, powder, >=98% (TLC)
  • Alpha-Hydroxyalprazolam, 1mg/ml in Methanol
  • beta-hydroxyalprazolam
  • alpha-Hydroxyalprazolam 1.0 mg/ml in Methanol
  • 6-phenyl-8-chloro-4H-s-triazolo [ 4,3-a][1,4]benzodiazepine-1-methanol
  • 1-Hydroxy Alprazolam
  • 6-PHENYL-8-CHLORO-4H-S-TRIAZOLO(4,3-A)BENZODIAZEPINE-1-METHANOL
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-1-methanol,8-chloro-6-phenyl-
  • 1-(hydroxymethyl)-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
  • 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-methanol
  • Q27291633
  • NS00010429

MDL Number

MFCD00171226

Customs Code

2933990090

FAQ

What regulatory guidelines apply to (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8)?
The (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8) is subject to regulatory guidelines such as GHS classification for hazardous chemicals, REACH regulations for EU market, and FDA/EPA requirements for pharmaceutical and environmental safety. Specific handling, storage, and disposal practices must comply with these guidelines to ensure safety and regulatory compliance.

Are there alternatives to (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8) in synthesis?
There are alternatives to (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8) in synthesis, such as other triazolo-benzodiazepines with varying substituents. Common alternatives include using different chloro-substituted benzodiazepines or isomers, which can offer similar or different properties depending on the specific application.

What is the market or research trend for (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8)?
The market and research trends for (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8) are focused on its potential applications in pharmaceuticals, particularly for anti-inflammatory and anti-cancer treatments. Research is also exploring its use in drug delivery systems and as a precursor for other bioactive compounds. Price trends show stability with increasing demand from pharmaceutical industries.

How should waste containing (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8) be handled?
Waste containing (8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol (CAS: 37115-43-8) should be collected in appropriate containers and labeled as hazardous waste. Proper handling includes ensuring minimal exposure and contamination. Professional waste disposal services should be utilized to ensure safe incineration or other methods in compliance with local environmental regulations. Protective measures and training are essential for handling and disposal.

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(8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-yl)methanol — ShenZhenAiTaHuaXue Co Ltd

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