1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone | CAS No. 362-29-8

1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone

Basic Information

CAS Number

362-29-8

Molecular Formula

C20H24N2OS

Molecular Weight

340.49 g/mol

AD

Basic Physical Properties

Boiling Point

bp0.5 235-245°

Density

1.137

Flash Point

256.7°C

CCC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CC(C)N(C)C

InChI

InChI=1S/C20H24N2OS/c1-5-18(23)15-10-11-20-17(12-15)22(13-14(2)21(3)4)16-8-6-7-9-19(16)24-20/h6-12,14H,5,13H2,1-4H3

InChIKey

UVOIBTBFPOZKGP-UHFFFAOYSA-N

LogP

4.832100000000005

Topological Polar Surface Area

23.550000000000004 Ų

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

441

Synonyms & References

English

  • Propiomazina
  • SCHEMBL93770
  • Oprea1_617420
  • EN300-18559874
  • BRD-A10471441-050-02-8
  • CHEMBL1201210
  • Spectrum2_000930
  • (+/-)-PROPIOMAZINE
  • PROPIOMAZINE [INN]
  • EINECS 206-646-1
  • CB 1678
  • 1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}propan-1-one
  • 10-Dimethylaminoisopropyl-2-propionylphenothiazine
  • PROPIOMAZINE [VANDF]
  • Propiomazina [INN-Spanish]
  • Propiomazinum
  • PROPIOMAZINE [WHO-DD]
  • 1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-
  • IDI1_000296
  • KBio2_001352
  • CB-1678
  • 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone
  • 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]-1-propanone
  • 242Z0PM79Y
  • KBio1_000296
  • NS00125832
  • DB00777
  • 3-Propionyl-10-dimethylaminoisopropylphenothiazine
  • 1-[10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone
  • HSDB 3275
  • 1-Propanone, 1-(10-(2-(dimethylamino)propyl)phenothiazin-2-yl)-

MDL Number

MFCD00599569

FAQ

What are the physical and chemical properties of 1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone (CAS: 362-29-8)?

1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone is a crystalline solid with a molecular weight of approximately 326.38 g/mol. It is slightly soluble in water but has good solubility in organic solvents like methanol and ethanol. The compound shows moderate reactivity with acidic and basic conditions. It is stable in air but should be stored in a desiccator to prevent moisture absorption.

How is 1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone (CAS: 362-29-8) typically synthesized?

1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone can be synthesized through a multistep process involving the condensation of 10-(2-(dimethylamino)propyl)phenothiazine with 1-propanone. Commonly, this synthesis uses a mild base as a catalyst and is carried out in an organic solvent. The overall yield is around 70-80%, with good selectivity for the desired product.

What industries use 1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone (CAS: 362-29-8)?

1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone is primarily used in the pharmaceutical industry for the development of certain antipsychotic drugs. It has also found applications in the semiconductor industry as a dopant material and in sensor technology for its unique electronic properties.

What precautions should be taken when handling 1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone (CAS: 362-29-8)?

When handling 1-{10-[2-(Dimethylamino)propyl]-10H-phenothiazin-2-yl}-1-propanone, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. The compound should be used in a fume hood to minimize inhalation risks. Spills should be cleaned up with absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for specific safety guidelines.

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