2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole

Basic Information

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CAS Number

3613-73-8

Molecular Formula

C21H25N3

Molecular Weight

319.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

448.46°C (rough estimate)

Refractive Index

1.6380 (estimate)

SMILES

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Cc1ccc2c(c1)c3c(n2CCc4ccc(nc4)C)CCN(C3)C

InChI

InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3

InChIKey

JNODQFNWMXFMEV-UHFFFAOYSA-N

LogP

3.883740000000002

Topological Polar Surface Area

21.060000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

425

Synonyms & References

English

Dimebolin
2,3,4,5-Tetrahydro-2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-1H-pyrido[4,3-b]indole
2,8-dimethyl-5-[2-(6-methylpyridin-3-yl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole
Dimebon
DIMEBON (DIMEBOLIN)
Dimebone
aka latrepiridine
Dimeboline
Latrepirdine
Preparation 84

MDL Number

MFCD00387540

FAQ

What are the physical and chemical properties of 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (CAS: 3613-73-8)?

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is a solid with a crystalline form. The molecular weight is approximately 358.39 g/mol. Its solubility in water is low, but it is more soluble in organic solvents like methanol and ethanol. The compound is less reactive, showing minimal reactivity with common reagents. It is stable under normal laboratory conditions.

How is 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (CAS: 3613-73-8) typically synthesized?

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is typically synthesized via a multi-step process involving the reaction of a pyridine derivative with an ethylenediamine derivative. The synthesis requires careful control of temperature and reagent equivalents to achieve high yield and selectivity. Catalysts such as palladium(II) acetate may be used to enhance the reaction efficiency.

What industries use 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (CAS: 3613-73-8)?

2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is used in the pharmaceutical industry for the development of potential drug candidates. It may also find applications in the polymer industry for the development of novel materials with specific properties. Additionally, it could be used in the sensor and semiconductor industries for the fabrication of specialized devices.

What precautions should be taken when handling 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (CAS: 3613-73-8)?

When handling 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole, it is essential to use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area, preferably in a fume hood. Spills should be cleaned up immediately using appropriate absorbents and following the manufacturer's guidelines. Always consult the Safety Data Sheet (SDS) for specific handling and disposal instructions.