(2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite | CAS No. 330628-04-1

(2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

Basic Information

CAS Number

330628-04-1

Molecular Formula

C43H53N8O7P

Molecular Weight

824.9 g/mol

AD

Basic Physical Properties

Solubility

Insuluble (9.1E-5 g/L) (25 ºC),

CC(N(C(C)C)P(O[C@@H]1[C@@H](COC(C2=CC=C(OC)C=C2)(C3=CC=C(OC)C=C3)C4=CC=CC=C4)O[C@@H](N5C=NC6=C5NC(/N=C/N(C)C)=NC6=O)C1)OCCC#N)C

InChI

1S/C43H53N8O7P/c1-29(2)51(30(3)4)59(56-24-12-23-44)58-36-25-38(50-28-45-39-40(50)47-42(48-41(39)52)46-27-49(5)6)57-37(36)26-55-43(31-13-10-9-11-14-31,32-15-19-34(53-7)20-16-32)33-17-21-35(54-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H,47,48,52)/b46-27+/t36-,37+,38+,59?/m0/s1

InChIKey

YRQAXTCBMPFGAN-UNHDIWNRSA-N

LogP

7.31558

Complexity

1410

Synonyms & References

English

  • N4-(DIMETHYLAMINO)METHYLENE)-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE
  • 2'-DEOXY-N2-DMF-5'-O-DMT-GUANOSINE 3'-CE PHOSPHORAMIDITE
  • dmf-dG-CE-Phophoramidite
  • N2-DMF-5'-O-DMT-2’-deoxyguanosine-3'-CE Phosphoramidite
  • N2-dimethylformamidine-2'-deoxyguanosine-3'-diisopropylaminocyanoethyl phosphoramidite
  • REF DUPL: DMF-dG-CE-Phophoramidite
  • N-[(dimethylamino)methylene]-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
  • N2-Dimethylformamidine-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]
  • DMF-dG Phosphoramidite
  • EBD296414
  • 5'-O-DMT-N2-(dimethylamino)-2'-Deoxy Guanosine Phosphoramidite
  • N4-(Dimethylamino)methylene)-5 inverted exclamation mark -O-(dimethoxytrityl)-2 inverted exclamation mark -deoxyguanosine-3 inverted exclamation mark -N,N-diisopropyl(cyanoethyl) phosphoramidite
  • 5'-O-(4,4'-dimethoxytrityl)-N-
  • N'-[9-[(2R,4S,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)am
  • 5'-O-DMT-2'-dG(DMF) Phosphor amidite
  • DMT-dG(dmf) Phosphoramidite

MDL Number

MFCD00797420

FAQ

What is (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS: 330628-04-1)?

This compound is a phosphoramidite derivative with a complex structure. It contains a tetrahydrofuran ring, a purine moiety, and a phosphoryl group. The compound is used in organic synthesis, particularly in the preparation of oligonucleotides for pharmaceuticals and biotechnology applications.

What are the main uses of (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS: 330628-04-1)?

This compound is primarily used in the synthesis of oligonucleotides for drug development, DNA and RNA research, and as a key reagent in the production of certain pharmaceuticals. It plays a critical role in the production of oligonucleotide-based drugs and diagnostics.

Is (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS: 330628-04-1) safe?

The compound is generally safe when handled with appropriate precautions. It is important to follow standard safety protocols, including wearing protective gloves and goggles, and working in a well-ventilated area. Proper storage and disposal procedures should also be followed to minimize risks.

How should (2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((dimethylamino)methylene)amino)-6-oxo-3H-purin-9(6H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS: 330628-04-1) be stored?

The compound should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent exposure to moisture and air. Temperatures should be maintained below 25°C (77°F) to ensure stability.

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