2-Bromo-1-(1,3-thiazol-2-yl)ethanone

Basic Information

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CAS Number

3292-77-1

Molecular Formula

C5H4BrNOS

Molecular Weight

206.06 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

54-55 ºC

Boiling Point

266.7°C at 760 mmHg

SMILES

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C1=CSC(=N1)C(=O)CBr

InChI

InChI=1S/C5H4BrNOS/c6-3-4(8)5-7-1-2-9-5/h1-2H,3H2

InChIKey

AQRFTRDAOYSMEA-UHFFFAOYSA-N

LogP

1.7207

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

120

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

BP-20204
2-bromoacetylthiazole
2-Bromo-1-(2-thiazolyl)-ethanone
AM100666
CS-D0891
AKOS005069284
2-bromo-1-(1,3-thiazol-2-yl)ethanone
SY042806
AQRFTRDAOYSMEA-UHFFFAOYSA-N
SCHEMBL230444
3292-77-1
W-202351
2-bromoacetyl thiazole
1-BROMO-(1,3-THIAZOLE-2-YL)ETHANE-2-ONE
FT-0679925
A821523
2-(BROMOACETYL)-1,3-THIAZOLE
2-Bromo-1-(1,3-thiazol-2-yl)-1-ethanone
BCP07589
2-bromo-1-(1,3-thiazol-2-yl)ethan-1-one
A5886
EN300-176891
DTXSID20383584
2-bromo-1-(1,3-thiazol-2-yl)ethanone, AldrichCPR
Ethanone, 2-bromo-1-(2-thiazolyl)-
2-bromo-1-(thiazol-2-yl)ethanone
MFCD06411540
2-bromo-1-(thiazol-2-yl)-ethanone
10T-0046
BL005497
2-Bromo-1-thiazol-2-yl-ethanone

MDL Number

MFCD06411540

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 2-Bromo-1-(1,3-thiazol-2-yl)ethanone (CAS: 3292-77-1)?

2-Bromo-1-(1,3-thiazol-2-yl)ethanone is a crystalline compound with a molecular weight of approximately 258.12 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetone and methanol. This compound exhibits moderate reactivity, particularly towards nucleophiles and reducing agents. It is often used as a precursor in organic synthesis and displays potential in medicinal chemistry.

How is 2-Bromo-1-(1,3-thiazol-2-yl)ethanone (CAS: 3292-77-1) typically synthesized?

2-Bromo-1-(1,3-thiazol-2-yl)ethanone is typically synthesized via the reaction of 1-(1,3-thiazol-2-yl)ethanone with bromine in the presence of an appropriate solvent. This process requires careful control of reaction conditions to achieve high yield and selectivity. Common solvents include acetic acid or acetonitrile, and the reaction is often performed under anhydrous conditions to prevent side reactions.

What industries use 2-Bromo-1-(1,3-thiazol-2-yl)ethanone (CAS: 3292-77-1)?

2-Bromo-1-(1,3-thiazol-2-yl)ethanone is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various bioactive compounds and is also explored for its potential applications in sensor technology and catalysis. Its use in these sectors highlights its importance in research and development.

What precautions should be taken when handling 2-Bromo-1-(1,3-thiazol-2-yl)ethanone (CAS: 3292-77-1)?

When handling 2-Bromo-1-(1,3-thiazol-2-yl)ethanone, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be handled carefully using appropriate absorbents, and proper disposal methods should be followed as outlined in the Safety Data Sheet (SDS). Always follow safety guidelines and consult the SDS for detailed instructions.