3-(Trifluoromethoxy)benzohydrazide

Basic Information

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CAS Number

321195-88-4

Molecular Formula

C8H7F3N2O2

Molecular Weight

220.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

94-96°C

SMILES

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C1=CC(=CC(=C1)OC(F)(F)F)C(=O)NN

InChI

InChI=1S/C8H7F3N2O2/c9-8(10,11)15-6-3-1-2-5(4-6)7(14)13-12/h1-4H,12H2,(H,13,14)

InChIKey

MNEXCWJCDZXJLF-UHFFFAOYSA-N

LogP

1.1886999999999996

Topological Polar Surface Area

64.35 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

232

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Air Sensitive

Synonyms & References

English

CS-0333052
SCHEMBL679553
321195-88-4
DTXSID60396618
MFCD03425698
3-(Trifluoromethoxy)benzhydrazide
FT-0676579
A875708
3-(trifluoromethoxy)benzohydrazide
SB86383
EN300-6221684
3-Trifluoromethoxybenzoic acid hydrazide
3-trifluoromethoxy-benzoic acid hydrazide
AKOS015853109
3-(Trifluoromethoxy)benzohydrazide
3-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE
Benzoic acid,3-(trifluoromethoxy)-, hydrazide

MDL Number

MFCD03425698

Customs Code

2928000090

FAQ

What are the physical and chemical properties of 3-(Trifluoromethoxy)benzohydrazide (CAS: 321195-88-4)?

3-(Trifluoromethoxy)benzohydrazide is a white crystalline solid with a molecular weight of approximately 249.06 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol. This compound is known for its good stability and low reactivity under normal conditions. It can be easily hydrolyzed under basic conditions, making it sensitive to strong bases.

How is 3-(Trifluoromethoxy)benzohydrazide (CAS: 321195-88-4) typically synthesized?

3-(Trifluoromethoxy)benzohydrazide is typically synthesized through the condensation reaction between 3-(trifluoromethoxy)benzaldehyde and hydrazine hydrate. The reaction is generally performed in a suitable solvent like ethanol under mild conditions. The yield is usually high, and the product can be purified by recrystallization from ethanol.

What industries use 3-(Trifluoromethoxy)benzohydrazide (CAS: 321195-88-4)?

3-(Trifluoromethoxy)benzohydrazide is used in various industries, particularly in pharmaceuticals for the synthesis of certain drug candidates. It is also used in the production of organofluorine compounds and as a precursor in the development of functional materials, including sensors and semiconductors.

What precautions should be taken when handling 3-(Trifluoromethoxy)benzohydrazide (CAS: 321195-88-4)?

Proper handling of 3-(Trifluoromethoxy)benzohydrazide requires the use of appropriate Personal Protective Equipment (PPE), including gloves, safety goggles, and laboratory coat. Handling should be done in a well-ventilated area or a fume hood to prevent inhalation of fumes. Spills should be cleaned up immediately using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.