3-(Trifluoromethoxy)benzohydrazide(CAS: 321195-88-4)

3-(Trifluoromethoxy)benzohydrazide is a white crystalline solid with a molecular weight of approximately 249.06 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol. This compound is known for its good stability and low reactivity under normal conditions. It can be easily hydrolyzed under basic conditions, making it sensitive to strong bases.

3-(Trifluoromethoxy)benzohydrazide is typically synthesized through the condensation reaction between 3-(trifluoromethoxy)benzaldehyde and hydrazine hydrate. The reaction is generally performed in a suitable solvent like ethanol under mild conditions. The yield is usually high, and the product can be purified by recrystallization from ethanol.

3-(Trifluoromethoxy)benzohydrazide is used in various industries, particularly in pharmaceuticals for the synthesis of certain drug candidates. It is also used in the production of organofluorine compounds and as a precursor in the development of functional materials, including sensors and semiconductors.

Proper handling of 3-(Trifluoromethoxy)benzohydrazide requires the use of appropriate Personal Protective Equipment (PPE), including gloves, safety goggles, and laboratory coat. Handling should be done in a well-ventilated area or a fume hood to prevent inhalation of fumes. Spills should be cleaned up immediately using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.