Nocodazole | CAS No. 31430-18-9

Nocodazole

Basic Information

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CAS Number

31430-18-9

Molecular Formula

C14H11N3O3S

Molecular Weight

301.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

300 °C (dec.)

Solubility

DMSO: 10 mg/mL, soluble

Refractive Index

1.6740 (estimate)

SMILES

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COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

InChI

InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)

InChIKey

KYRVNWMVYQXFEU-UHFFFAOYSA-N

LogP

3.0337000000000014

Topological Polar Surface Area

84.07999999999998 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

420

Safety Information

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Hazard Statement

H341 Suspected of causing genetic defects
Germ cell mutagenicity

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

HMS1792B03
M 1404
NCGC00015647-06
R17934
NCGC00025058-05
HMS2095C22
methyl (5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate
AC-25615
AM807900
NCGC00025058-04
SW102861-5
Cambridge id 5175348
NCGC00015647-13
EX-A5289
Spectrum4_001060
NSC 238159
NSC 238 159
KBioGR_000322
MLS000860046
UNII-SH1WY3R615
CCG-208075
HMS2094G13
QTL1_000062
N-[6-[oxo(thiophen-2-yl)methyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester
HMS3403B03
NCI60_001911
N1138
Methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate
SCHEMBL9477
KBio2_005458

MDL Number

MFCD00005588

Customs Code

2934999090

FAQ

What is Nocodazole (CAS: 31430-18-9)?

Nocodazole is a benzoquinone ansamycin antibiotic with the chemical formula C27H26N2O6. It is known for its ability to disrupt microtubule function by binding to tubulin, making it a potent inhibitor of cell division and a useful tool in cancer research. It also has potential applications in the treatment of neurodegenerative diseases.

What are the main uses of Nocodazole (CAS: 31430-18-9)?

Nocodazole is primarily used as an antimitotic agent in cancer research, where it inhibits cell division by interfering with microtubule assembly. It is also studied for potential therapeutic applications in neurodegenerative diseases and as a research tool in cell biology.

Is Nocodazole (CAS: 31430-18-9) safe?

Nocodazole can be hazardous and requires proper handling. It is classified as a skin and eye irritant and may cause allergic reactions. Adequate protective measures such as gloves, goggles, and lab coats should be worn during handling. It should be stored away from heat and light in a secure, labeled container.

How should Nocodazole (CAS: 31430-18-9) be stored?

Nocodazole should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept in a tightly sealed container to prevent degradation. The storage temperature should not exceed 25°C, and it should be protected from moisture and light exposure to maintain its stability and safety.