Ethyl 1-methyl-2-piperidinecarboxylate

Basic Information

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CAS Number

30727-18-5

Molecular Formula

C9H17NO2

Molecular Weight

171.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

95°C/16mmHg

Flash Point

73 ºC

Refractive Index

1.451-1.454

SMILES

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CCOC(=O)C1CCCCN1C

InChI

InChI=1S/C9H17NO2/c1-3-12-9(11)8-6-4-5-7-10(8)2/h8H,3-7H2,1-2H3

InChIKey

ZICBNHLULHJETL-UHFFFAOYSA-N

LogP

1.0338

Topological Polar Surface Area

29.54 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

159

Safety Information

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Hazard Statement

H227 Combustible liquid
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

1-methylpipe-ridine-2-carboxylic acid ethyl ester
1-Methyl-2-piperidinecarboxylic Acid Ethyl Ester
Ethyl 1-methylpiperidine-2-carboxylate
Ethyl 1-methyl-2-piperidinecarboxylate #
Ethyl N-methylpipecolinate
AC-22459
Ethyl1-methylpipecolinate
N-Methyl-piperidine-2-carboxylic acid ethyl ester
SY023682
Ethyl 1-methyl-2-piperidinecarboxylate
CS-0030554
InChI=1/C9H17NO2/c1-3-12-9(11)8-6-4-5-7-10(8)2/h8H,3-7H2,1-2H3
NS00050875
W-106931
SB42949
1-Methylpipecolinic Acid Ethyl Ester
AKOS016050386
ZICBNHLULHJETL-UHFFFAOYSA-
A820584
SCHEMBL652160
Ethyl 1-methylpipecolinate
Ethyl 1-Methylpipecolate
E0864
Methyl 1-methyl Piperidine-2-carboxylate
30727-18-5
Z104478932
AM20090432
EINECS 250-311-2
2-Carbethoxy-N-methylpiperidine
1-Methylpipecolic Acid Ethyl Ester
ETHYL N-METHYL PIPERIDINE-2-CARBOXYLATE

MDL Number

MFCD00006492

Customs Code

2933399090

FAQ

What are the physical and chemical properties of Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5)?

Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5) is a colorless to light yellow liquid with a molecular weight of approximately 166.25 g/mol. It has a distinct odor and is soluble in common organic solvents such as ethanol, acetone, and dichloromethane. The compound is moderately reactive, especially in acidic conditions, and can undergo ester hydrolysis. It is stable under normal conditions but should be stored away from strong acids and bases.

How is Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5) typically synthesized?

Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5) is typically synthesized via a condensation reaction between 1-methyl-2-piperidinecarboxylic acid and ethanol. The reaction can be catalyzed by a strong base like sodium hydride or by using a coupling reagent such as DCC (dicyclohexylcarbodiimide). The yield is generally high, and the product can be purified by column chromatography or recrystallization.

What industries use Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5)?

Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5) is used in the pharmaceutical industry for the synthesis of various drugs, particularly those that require ester functionalities. It is also used in the polymer industry as a monomer or modifier. Additionally, it has applications in sensors and as a chemical intermediate in the production of organic compounds.

What precautions should be taken when handling Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5)?

When handling Ethyl 1-methyl-2-piperidinecarboxylate (CAS: 30727-18-5), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat sources and incompatible materials. Spills should be handled carefully, using appropriate absorbents, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.