6-Acetamido-2-pyridinecarboxylic acid

Basic Information

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CAS Number

26893-72-1

Molecular Formula

C8H8N2O3

Molecular Weight

180.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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CC(=O)NC1=CC=CC(=N1)C(=O)O

InChI

InChI=1S/C8H8N2O3/c1-5(11)9-7-4-2-3-6(10-7)8(12)13/h2-4H,1H3,(H,12,13)(H,9,10,11)

InChIKey

LOMWKYHCHCZVCC-UHFFFAOYSA-N

LogP

0.7381999999999997

Topological Polar Surface Area

79.29 Å²

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

217

Synonyms & References

English

Z223026202
AC-907/34126046
6-Acetamidopicolinicacid,6-(Acetylamino)pyridine-2-carboxylicacid
6-acetylaminopyridine-2-carboxylic acid
MFCD00233707
AML0068
MLS000704785
SB52862
FT-0687912
6-Acetamidopicolinic acid, 6-(Acetylamino)pyridine-2-carboxylic acid
AS-48013
6-Acetylamino-pyridine-2-carboxylic acid
6-(acetylamino)-2-pyridinecarboxylic acid
EN300-26425
LOMWKYHCHCZVCC-UHFFFAOYSA-N
J-518190
2-acetylaminopyridine-6-carboxylic acid
6-(acetylamino)-2-pyridinecarboxylic acid, AldrichCPR
6-Acetylamino-2-pyridinecarboxylic acid
AKOS001289630
HMS2620F21
6-(acetylamino)pyridine-2-carboxylic acid
DTXSID30356461
6-acetamidopyridine-2-carboxylic acid
SCHEMBL2251120
NS00123248
26893-72-1
A877106
6-Acetamidopicolinic acid
SMR000230414
F17538

MDL Number

MFCD00233707

FAQ

What are the physical and chemical properties of 6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1)?

6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1) is a white crystalline solid with a molecular weight of approximately 227.21 g/mol. It is slightly soluble in water and is moderately soluble in hot water. The compound is known for its reactivity towards nucleophilic substitution and amide hydrolysis. It has a pKa of approximately 2.1 in aqueous solution.

How is 6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1) typically synthesized?

6-Acetamido-2-pyridinecarboxylic acid is typically synthesized through a multi-step process involving the condensation of 2-pyridinecarboxylic acid with acetic anhydride in the presence of a catalytic amount of an acid or base. The reaction is carried out in a suitable solvent such as ethanol or toluene, yielding a high purity product with good selectivity and a yield of around 80-85%.

What industries use 6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1)?

6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1) is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer for the production of certain polymers with unique properties. Additionally, it can be used in the development of sensors and as a building block in semiconductor manufacturing.

What precautions should be taken when handling 6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1)?

When handling 6-Acetamido-2-pyridinecarboxylic acid (CAS: 26893-72-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat to protect against skin and eye contact. The compound should be stored in a dry, cool place away from heat sources and incompatible materials. In case of a spill, the area should be thoroughly cleaned with water and appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.