2-Chloro-4-methyl-1,3-thiazole

Basic Information

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CAS Number

26847-01-8

Molecular Formula

C4H4ClNS

Molecular Weight

133.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

203 ºC

Flash Point

76 ºC

SMILES

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CC1=CSC(=N1)Cl

InChI

InChI=1S/C4H4ClNS/c1-3-2-7-4(5)6-3/h2H,1H3

InChIKey

SYDUUJIIXIOTQT-UHFFFAOYSA-N

LogP

2.10492

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

68.7

Synonyms & References

English

2-chloro-4-methyl-1,3-thiazole
NS00028211
SB15813
AC-27364
AM803610
BS-12697
2-Chloro-4-methyl-thiazole
2-Chloro-4-methylthiazole
SYDUUJIIXIOTQT-UHFFFAOYSA-N
EINECS 248-046-2
DTXSID20181365
CS-0054447
BL002552
26847-01-8
SY128140
FT-0647553
SCHEMBL112097
EN300-28534
A5268
MFCD00051033
AKOS002657898
J-508770
2-CHLORO-4-METHYL-THIAZOLE
Thiazole, 2-chloro-4-methyl-
2-Chlor-4-methyl-thiazol
2-chloro-4-methyl-thiazol
2-Chlorr-4-methylthiazol
2-Chloro-4-methyl-1,3-thiazol
4-Methyl-2-chlorothiazole

MDL Number

MFCD00051033

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 2-Chloro-4-methyl-1,3-thiazole (CAS: 26847-01-8)?

2-Chloro-4-methyl-1,3-thiazole is a crystalline solid with a molecular weight of approximately 147.59 g/mol. It has a melting point of 115-118°C and is slightly soluble in water. The compound is known for its reactivity, particularly towards nucleophiles and electrophiles, and it exhibits good stability under neutral to slightly acidic conditions.

How is 2-Chloro-4-methyl-1,3-thiazole (CAS: 26847-01-8) typically synthesized?

2-Chloro-4-methyl-1,3-thiazole is commonly synthesized via the addition of chloromethyl methyl ether to thioacetic acid in the presence of a base like sodium hydride. The reaction typically yields 2-Chloro-4-methyl-1,3-thiazole in moderate to good yield, and the methodology is known for its good selectivity.

What industries use 2-Chloro-4-methyl-1,3-thiazole (CAS: 26847-01-8)?

2-Chloro-4-methyl-1,3-thiazole is used in various industries, including pharmaceuticals, where it serves as a precursor for drug synthesis, and in the production of polymers and sensors. It is also utilized in the synthesis of certain agrochemicals and as an intermediate in semiconductor manufacturing.

What precautions should be taken when handling 2-Chloro-4-methyl-1,3-thiazole (CAS: 26847-01-8)?

When handling 2-Chloro-4-methyl-1,3-thiazole, it is important to use appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate procedures, and the substance should be stored in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.