1,8-naphthyridine

Basic Information

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CAS Number

254-60-4

Molecular Formula

C8H6N2

Molecular Weight

130.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

95.0 to 99.0 deg-C

Boiling Point

248.9°C at 760 mmHg

SMILES

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C1=CC2=C(N=C1)N=CC=C2

InChI

InChI=1S/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6H

InChIKey

FLBAYUMRQUHISI-UHFFFAOYSA-N

LogP

1.6298

Topological Polar Surface Area

25.78 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

102

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

对湿度敏感

Synonyms & References

English

1,8-Pyridopyridine
FT-0631893
N0464
[1,8]Naphthyridine
InChI=1/C8H6N2/c1-3-7-4-2-6-10-8(7)9-5-1/h1-6
1,8 naphthyridine
1,8-Diazanaphthalene
043R04VL4M
EN300-94649
CHEMBL261758
MFCD00059751
CS-W002277
Z1201618482
254-60-4
SCHEMBL3713892
Pyrido[2,3-b]pyridine
Q19961826
SCHEMBL9559247
1,8-napthyridine
SCHEMBL8193
CHEBI:36628
napy
SY021105
W3P
1,8-Diazanapthalene
DTXSID40180052
AM20070185
naphthyridine
AC-9573
AB02373
UNII-043R04VL4M

MDL Number

MFCD00059751

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 1,8-naphthyridine (CAS: 254-60-4)?

1,8-naphthyridine (CAS: 254-60-4) is a crystalline solid with a molecular weight of approximately 135.14 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. Chemically, it is less reactive compared to other pyridine derivatives, exhibiting basic properties due to the presence of an amino group.

How is 1,8-naphthyridine (CAS: 254-60-4) typically synthesized?

1,8-naphthyridine (CAS: 254-60-4) can be synthesized via various methods, with one common route involving the condensation of 1,8-naphthyridone with ammonia. This process yields the compound with a good yield and high selectivity. Other methodologies include the direct amination of 1,8-naphthylamine or the reaction of 1,8-naphthoquinone with ammonia.

What industries use 1,8-naphthyridine (CAS: 254-60-4)?

1,8-naphthyridine (CAS: 254-60-4) finds applications in the pharmaceutical industry, where it serves as a precursor for the synthesis of certain drugs. It is also used in the development of polymer materials for sensors and semiconductors, benefiting from its unique electronic properties.

What precautions should be taken when handling 1,8-naphthyridine (CAS: 254-60-4)?

When handling 1,8-naphthyridine (CAS: 254-60-4), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate safety measures, and the material safety data sheet (MSDS) should be consulted for detailed guidelines on safe handling and disposal.