3-Methoxy-2-piperidinone

Basic Information

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CAS Number

25219-59-4

Molecular Formula

C6H11NO2

Molecular Weight

129.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

280 °C at 760 mmHg

Density

1.06

Flash Point

123.1 °C

Refractive Index

1.461

SMILES

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COC1CCCNC1=O

InChI

InChI=1S/C6H11NO2/c1-9-5-3-2-4-7-6(5)8/h5H,2-4H2,1H3,(H,7,8)

InChIKey

KCQXYISBJUBSAD-UHFFFAOYSA-N

LogP

-0.08860000000000018

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

114

Synonyms & References

English

2-Piperidinone, 3-methoxy-
SCHEMBL7211891
3-methoxy-2-piperidinone
CS-0197082
FT-0653110
EN300-23607459
DTXSID40629456
A817715
3-Methoxy-2-oxopiperidine
25219-59-4
AKOS006318711
O11031
3-METHOXY-2-PIPERIDONE
SB41206
3-Methoxypiperidin-2-one
MFCD12026381
AM20090301
AS-50134
(+-)-Methoxy-piperidin-2-on
2-Piperidinone,3-methoxy
3-Methoxy-2-piperidon
3-methoxy-piperidin-2-one
2-Piperidone,3-methoxy- (8CI)

MDL Number

MFCD12026381

Customs Code

2933790090

FAQ

What are the physical and chemical properties of 3-Methoxy-2-piperidinone (CAS: 25219-59-4)?

3-Methoxy-2-piperidinone (CAS: 25219-59-4) is a white crystalline solid with a molecular weight of approximately 148.17 g/mol. It has a solubility of about 10 g/L in water and is sparingly soluble in ethanol. The compound is mildly reactive, particularly towards nucleophiles, and is stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

How is 3-Methoxy-2-piperidinone (CAS: 25219-59-4) typically synthesized?

3-Methoxy-2-piperidinone (CAS: 25219-59-4) is typically synthesized via a multistep reaction involving the condensation of 1,4-dioxane-2,3-dione with methanol. The reaction is catalyzed by a strong base like sodium hydride, and the product is isolated by recrystallization. The process yields a product with high purity and good selectivity.

What industries use 3-Methoxy-2-piperidinone (CAS: 25219-59-4)?

3-Methoxy-2-piperidinone (CAS: 25219-59-4) is used in the pharmaceutical industry as a precursor for the synthesis of various drugs. It is also utilized in the polymer industry for the production of functional polymers, and in the chemical sensor industry for the development of new sensing materials. Additionally, it has applications in the semiconductor industry as a precursor for organic semiconductors.

What precautions should be taken when handling 3-Methoxy-2-piperidinone (CAS: 25219-59-4)?

When handling 3-Methoxy-2-piperidinone (CAS: 25219-59-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or fume hood due to its potential for inhalation hazards. In case of a spill, neutralize the area with an appropriate solvent and clean up using standard laboratory procedures. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.