1-(4-Fluorophenyl)piperazine

Basic Information

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CAS Number

2252-63-3

Molecular Formula

C10H13FN2

Molecular Weight

180.23 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

30-33 ºC

Boiling Point

118-123 ºC (0.1 mmHg)

Water Solubility

Insoluble in water.

Flash Point

>110 ºC

Refractive Index

1.5585-1.5605

SMILES

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C1CN(CCN1)C2=CC=C(C=C2)F

InChI

InChI=1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

InChIKey

AVJKDKWRVSSJPK-UHFFFAOYSA-N

LogP

1.2353

Topological Polar Surface Area

15.27 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

149

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

AVJKDKWRVSSJPK-UHFFFAOYSA-
EINECS 218-846-6
n-(4-fluorophenyl) piperazine
BIDD:GT0445
Flipiperazine
AKOS000101161
1-(4'-Fluorophenyl)piperazine
4(4-fluorophenyl)piperazine
PD048067
4-(4-fluoro-phenyl)piperazine
AC-3326
1-(p-Fluorophenyl)piperazine
1-(4-fluorophenyl)-piperazine
2252-63-3
1-(4-Fluorophenyl)piperazine, 98%
FT-0605725
1-(4-fluoro phenyl) piperazine
4-Fluoro-phenylpiperazine
BB 0259246
UNII-VML61BE244
1-(4-Fluorophenyl)piperazine
pFPP
1-(4-fluorophenyl) piperazine
para-fluorophenylpiperazine
Piperazine, 1-(4-fluorophenyl)-
VML61BE244
1-(p-Fluorophenyl) piperazine
4-FPP
CHEMBL1184236
P-FLUOROPHENYLPIPERAZINE
4-(4-fluorophenyl)-piperazine

MDL Number

MFCD00005960

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3)?

1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) is a crystalline compound with a molecular weight of approximately 228.21 g/mol. It has a solubility of about 0.15 g/100 mL in water and is slightly soluble in ethanol. This compound is chemically stable but can react with strong acids and bases. It is an amine derivative known for its pharmacological activity.

How is 1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) typically synthesized?

1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) is typically synthesized via multistep organic reactions starting from 4-fluorophenol and piperazine. The synthesis involves protecting groups, coupling reactions, and deprotection steps. Commonly used catalysts and reagents include sodium hydroxide, dichloromethane, and pyridine. The overall yield is around 50-60%.

What industries use 1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3)?

1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) is primarily used in the pharmaceutical industry due to its receptor agonist properties. It is also utilized in the polymer industry for its potential as a stabilizer. Additionally, it is explored for use in sensors and semiconductors for its electronic properties.

What precautions should be taken when handling 1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3)?

When handling 1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3), appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. In case of a spill, immediately clean up with appropriate absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.