1-(4-Fluorophenyl)piperazine(CAS: 2252-63-3)

1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) is a crystalline compound with a molecular weight of approximately 228.21 g/mol. It has a solubility of about 0.15 g/100 mL in water and is slightly soluble in ethanol. This compound is chemically stable but can react with strong acids and bases. It is an amine derivative known for its pharmacological activity.

1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) is typically synthesized via multistep organic reactions starting from 4-fluorophenol and piperazine. The synthesis involves protecting groups, coupling reactions, and deprotection steps. Commonly used catalysts and reagents include sodium hydroxide, dichloromethane, and pyridine. The overall yield is around 50-60%.

1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3) is primarily used in the pharmaceutical industry due to its receptor agonist properties. It is also utilized in the polymer industry for its potential as a stabilizer. Additionally, it is explored for use in sensors and semiconductors for its electronic properties.

When handling 1-(4-Fluorophenyl)piperazine (CAS: 2252-63-3), appropriate personal protective equipment (PPE) including gloves, safety goggles, and lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. In case of a spill, immediately clean up with appropriate absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage information.