5-bromo-2-chloro-pyrimidin-4-amine

Basic Information

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CAS Number

205672-25-9

Molecular Formula

C4H3BrClN3

Molecular Weight

208.45 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

189 °C

Water Solubility

Slightly soluble in water.

Flash Point

177.5℃

SMILES

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C1=C(C(=NC(=N1)Cl)N)Br

InChI

InChI=1S/C4H3BrClN3/c5-2-1-8-4(6)9-3(2)7/h1H,(H2,7,8,9)

InChIKey

QOWALNIZDHZTSM-UHFFFAOYSA-N

LogP

1.4747

Topological Polar Surface Area

51.8 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

102

Safety Information

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Hazard Statement

H301 Toxic if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

AMY245
DTXSID00376878
A4471
SCHEMBL246368
DS-0196
MFCD07782040
4-amino-5-bromo-2-chloropyrimidine, AldrichCPR
BCP26488
W-206534
4-Amino-5-bromo-2-chloropyrimidine
205672-25-9
PB34247
SY007045
5-Bromo-2-chloropyrimidin-4-ylamine
CS-W003431
EN300-171907
4-Pyrimidinamine, 5-bromo-2-chloro-
QOWALNIZDHZTSM-UHFFFAOYSA-N
5-BROMO-2-CHLORO-4-PYRIMIDINAMINE
Ethanone,1-(4-amino-2-methylphenyl)-(9CI)
5-bromo-2-chloro-pyrimidin-4-ylamine
FT-0646998
PS-3821
AKOS005259589
5-bromo-2-chloropyrimidin-4-amine
AC-8524
5-Bromo-2-chloropyrimidin-4-amine
4-amino-2-chloro-5-bromopyrimidine
4-Pyrimidinamine,5-bromo-2-chloro
5-bromo-2-chloro-4-pyrimidinamine
5-bromo-2-chloropyrimidin-4-ylamine

MDL Number

MFCD07782040

Customs Code

2933599090

FAQ

What are the physical and chemical properties of 5-bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9)?

5-Bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9) is a crystalline solid with a molecular weight of approximately 227.03 g/mol. It has a melting point around 115-118°C and is slightly soluble in water. This compound is known for its reactivity in nucleophilic substitution reactions and can form stable complexes with various metals.

How is 5-bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9) typically synthesized?

5-Bromo-2-chloro-pyrimidin-4-amine is typically synthesized through a multi-step process involving the bromination and chlorination of pyrimidin-4-amine followed by amination. Common synthetic methods include the use of bromine and chlorine as reagents, and the reaction is often catalyzed by certain acids to improve yield and selectivity.

What industries use 5-bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9)?

5-Bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9) finds applications in the pharmaceutical industry due to its potential as an intermediate in drug synthesis. It is also used in the development of sensors and as a component in certain polymer formulations. Its versatile properties make it valuable in various research and development sectors.

What precautions should be taken when handling 5-bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9)?

When handling 5-bromo-2-chloro-pyrimidin-4-amine (CAS: 205672-25-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or under a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbents, and the area should be thoroughly rinsed. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety guidelines.