6-Fluoroquinazolin-2-amine | CAS No. 20028-72-2

6-Fluoroquinazolin-2-amine

Basic Information

CAS Number

20028-72-2

Molecular Formula

C8H6FN3

Molecular Weight

163.16 g/mol

AD

Basic Physical Properties

Boiling Point

373.7±34.0℃/760mmHg

C1=CC2=NC(=NC=C2C=C1F)N

InChI

InChI=1S/C8H6FN3/c9-6-1-2-7-5(3-6)4-11-8(10)12-7/h1-4H,(H2,10,11,12)

InChIKey

GYWBVSDGGRQXNQ-UHFFFAOYSA-N

LogP

1.3511

Topological Polar Surface Area

51.8 Ų

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

164

Synonyms & References

English

  • 6-fluoroquinazolin-2-amine
  • 6-Fluoroquinazolin-2-amine
  • 2-Amino-6-fluoroquinazoline
  • CS-0084750
  • DTXSID80733743
  • AC5166
  • A925995
  • MFCD12024575
  • SY224211
  • AKOS027441575
  • DB-066037
  • EN300-319526
  • 20028-72-2

MDL Number

MFCD12024575

FAQ

What regulatory guidelines apply to 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2)?

The 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2) falls under the classification of a hazardous substance due to its potential to irritate skin and eyes. It is regulated by the Globally Harmonized System of Classification and Labeling of Chemicals (GHS), REACH regulations in the EU, and FDA/EPA guidelines in the United States. Manufacturers and importers must provide safety data sheets (SDS) and ensure proper labeling. Compliance with local and national regulations is mandatory for handling, storage, and disposal.

Are there alternatives to 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2) in synthesis?

There are several alternatives to 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2) in synthesis, such as 6-chloroquinazolin-2-amine and 6-methoxyquinazolin-2-amine. Other routes include using related compounds like 4,7-dichloroquinazolin-2(3H)-one as a starting material. These alternatives can offer similar functional groups and properties with varying degrees of reactivity and synthesis complexity.

What is the market or research trend for 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2)?

The market for 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2) is growing due to its applications in drug discovery and development, particularly in the treatment of fungal infections. Research trends indicate a focus on its potential as a lead compound for antifungal drugs. Market dynamics include increasing demand from pharmaceutical companies and academic research institutions, driven by advancements in medicinal chemistry and the need for novel antifungal agents.

How should waste containing 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2) be handled?

Waste containing 6-Fluoroquinazolin-2-amine (CAS: 20028-72-2) should be collected in appropriate, labeled containers and stored in a secure, well-ventilated area. It should be handled by trained personnel using appropriate personal protective equipment (PPE). The waste should be neutralized if necessary, and disposed of through professional waste disposal services that comply with local and national regulations. Environmental protection measures should be taken to prevent contamination of soil and water.

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