2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate

Basic Information

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CAS Number

187237-37-2

Molecular Formula

C11H17N3O2

Molecular Weight

223.28 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

132-134℃

Boiling Point

132-134℃

Density

1.164

Flash Point

148.2℃

Refractive Index

1.568

SMILES

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CC(C)(C)OC(=O)NC1=NC=C(C=C1)CN

InChI

InChI=1S/C11H17N3O2/c1-11(2,3)16-10(15)14-9-5-4-8(6-12)7-13-9/h4-5,7H,6,12H2,1-3H3,(H,13,14,15)

InChIKey

DFLQTVPEIMTXSZ-UHFFFAOYSA-N

LogP

1.8873

Topological Polar Surface Area

77.24 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

238

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Sensitiveness

Air Sensitive

Synonyms & References

English

1-(4-Chloro-phenyl)-5-oxo-pyrrolidine-3-carboxylicacid
tert-butyl[5-(aminomethyl)pyridine-2-yl]carbamate
187237-37-2
2-Boc-Amino-5-(Aminomethyl)pyridine
tert-butyl N-[5-(aminomethyl)pyridin-2-yl]carbamate
tert-Butyl 5-(aminomethyl)-2-pyridinylcarbamate, AldrichCPR
EN300-3059611
2-(Boc-amino)-5-(aminomethyl)pyridine
FT-0603744
5-(Aminomethyl)-2-(N-BOC)Aminomethylpyridine
5-AMINOMETHYL-2-(BOC-AMINO)PYRIDINE
AM84958
tert-butyl [5-(aminomethyl)pyridine-2-yl]carbamate
W-206363
Carbamic acid, [5-(aminomethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester
SY006727
AC-22807
AB42565
tert-Butyl hydrogen [5-(aminomethyl)pyridin-2-yl]carbonimidate
MFCD07781132
AS-68298
SCHEMBL164105
TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE
A4143
DTXSID40940193
Q-103421
tert-butyl (5-(aminomethyl)pyridin-2-yl)carbamate
tert-butyl(5-(aminomethyl)pyridin-2-yl)carbamate
AKOS009462061
tert-butyl 5-(aminomethyl)pyridin-2-ylcarbamate
(5-(aminomethyl)pyridin-2-yl)carbamic acid tert-butyl ester

MDL Number

MFCD07781132

FAQ

What are the physical and chemical properties of 2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2)?

2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2) is a solid with a crystalline form. Its molecular weight is approximately 281.34 g/mol. This compound has moderate solubility in water and is highly soluble in organic solvents like methanol and dimethylformamide. It is moderately reactive, showing typical carbamate chemistry properties. It is stable under normal conditions but should be stored in a cool, dry place away from strong acids and bases.

How is 2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2) typically synthesized?

2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2) can be synthesized through a multi-step process involving the coupling of 2-methyl-2-propanol with 5-(aminomethyl)-2-pyridine-3-carboxylic acid chloride in the presence of a suitable base like triethylamine. The reaction typically results in a high yield (up to 90%) and good selectivity. Specific conditions and solvents are crucial for optimizing the reaction.

What industries use 2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2)?

2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2) finds application in the pharmaceutical industry, particularly in the synthesis of certain drugs due to its functional groups. It is also used in the development of sensors and as a building block in polymer chemistry for its reactivity and stability characteristics.

What precautions should be taken when handling 2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2)?

When handling 2-Methyl-2-propanyl [5-(aminomethyl)-2-pyridinyl]carbamate (CAS: 187237-37-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, lab coat, and safety goggles. This compound should be stored in a cool, dry place and away from strong acids and bases. Fume hoods should be used during handling to minimize exposure. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.