(4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline

Basic Information

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CAS Number

176486-63-8

Molecular Formula

C25H28N2O6

Molecular Weight

452.51 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

199 °C

Boiling Point

650.2°C at 760 mmHg

Flash Point

347°C

Refractive Index

1.627

SMILES

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CC(C)(C)OC(=O)N1CC(CC1C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

InChI

InChI=1S/C25H28N2O6/c1-25(2,3)33-24(31)27-13-15(12-21(27)22(28)29)26-23(30)32-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,30)(H,28,29)/t15-,21+/m1/s1

InChIKey

UPXRTVAIJMUAQR-VFNWGFHPSA-N

LogP

3.987700000000002

Topological Polar Surface Area

105.17 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

728

Synonyms & References

English

A881517
DS-15395
(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
(2S,4R)-4-[[[(9H-Fluoren-9-yl)methoxy]carbonyl]amino]-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
(2S,4R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylicacid
176486-63-8
N-Boc-trans-4-N-Fmoc-amino-L-proline
AM10121
(2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
J-011198
1,2-Pyrrolidinedicarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester, (2S,4R)-
(2S,4R)-N-(tert-Butoxycarbonyl)-4-N-(9-fluorenylmethoxycarbonyl)aminopyrrolidine-2-carboxylic acid
UPXRTVAIJMUAQR-VFNWGFHPSA-N
AKOS016007509
PD196576
N-Boc-trans-4-N-Fmoc-amino-L-proline, 97%
(2S,4R)-1-[(tert-butoxy)carbonyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidine-2-carboxylic acid
AKOS015995239
SCHEMBL1536521
CS-W008446
(2S,4R)-4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
HY-W008446
(2S,4R)-4-(((9H-fluoren-9-yl)methoxy)carbonylamino)-1-BOC-pyrrolidine-2-carboxylic acid
MFCD00673783
(2S,4R)-trans-N-alpha-t-Butyloxycarbonyl-4-(9-fluorenylmethyloxycarbonyl)amino-L-proline
N-?BOC-?TRANS-?4-?N-?FMOC-?AMINO-?D-?PROLINE
EN300-331976
(2S,4R)-Fmoc-4-Amino-1-Boc-Pyrrolidine-2-Carboxylic Acid
1,2-Pyrrolidinedicarboxylicacid,4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,1-(1,1-dimethylethyl)ester,(2S,4R)-
(2S,4R)-FMOC-4-AMINO-1-BOC-PYRROLIDINE-2-CARBOXYLIC ACID
(2S,4R)- 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

MDL Number

MFCD00673783

FAQ

What regulatory guidelines apply to (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8)?

The compound (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8) is subject to regulatory guidelines under REACH in the EU, which requires registration for substances above one tonne per year. It is also regulated by the EPA in the US for environmental and safety considerations. The FDA may also have specific requirements for its use in healthcare applications. Companies should consult the most recent regulatory databases for detailed compliance information.

Are there alternatives to (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8) in synthesis?

There are several alternatives to (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8) in synthesis, including related L-proline derivatives, fluorenecarbonyl amino acids, and other cyclic amino acids. These alternatives may offer similar functionalities but with varying reactivity and availability. Researchers should consider the specific requirements of their synthesis and choose the most suitable alternative based on the reaction conditions and desired product.

What is the market or research trend for (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8)?

The market for (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8) is primarily driven by its use as a building block in medicinal chemistry and drug discovery. Research trends suggest an increasing interest in its application in the development of new pharmaceuticals and biopharmaceuticals. Additionally, there is growing exploration of its use in polymer chemistry and materials science, driven by its unique properties and reactivity.

How should waste containing (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8) be handled?

Waste containing (4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline (CAS: 176486-63-8) should be managed according to local regulations and safety guidelines. Proper waste collection should be followed, and the waste should be neutralized and disposed of through incineration or professional waste disposal services. Environmental protection measures should include minimizing exposure to the environment and ensuring the waste is handled by certified professionals to prevent contamination and ensure safety.