2-Chloro-6-methoxyaniline

Basic Information

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CAS Number

158966-62-2

Molecular Formula

C7H8ClNO

Molecular Weight

157.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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COC1=C(C(=CC=C1)Cl)N

InChI

InChI=1S/C7H8ClNO/c1-10-6-4-2-3-5(8)7(6)9/h2-4H,9H2,1H3

InChIKey

SEZKSJHQUIRBCN-UHFFFAOYSA-N

LogP

1.9307999999999998

Topological Polar Surface Area

35.25 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

110

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Chloro-6-methoxyaniline
2-chloro-6-methoxyphenylamine
Benzenamine, 2-chloro-6-methoxy-
2-amino-3-chloroanisole
6-chloro-o-anisidine
2-chloro-6-methoxybenzenamine
SEZKSJHQUIRBCN-UHFFFAOYSA-N
SBB087239
CL9146
AM83274
TRA0058315
AK109648
AB0059743
Z4228
ST24022175
158966-62-2
SB76190
SY114665
CS-W019133
AKOS006221152
DTXSID50438475
MFCD14455911
DS-4384
SCHEMBL101875
EN300-42580
AN-584/43422706
DB-355917

MDL Number

MFCD14455911

FAQ

What are the physical and chemical properties of 2-Chloro-6-methoxyaniline (CAS: 158966-62-2)?

2-Chloro-6-methoxyaniline (CAS: 158966-62-2) is a crystalline solid with a molecular weight of approximately 178.62 g/mol. It has a pKa value of 6.5 and is slightly soluble in water. It is moderately reactive towards nucleophiles and is commonly used in organic synthesis. Its solubility in common organic solvents is relatively low, making it important in various industrial applications.

How is 2-Chloro-6-methoxyaniline (CAS: 158966-62-2) typically synthesized?

2-Chloro-6-methoxyaniline (CAS: 158966-62-2) is typically synthesized by the reaction of chloromethylbenzene with methanol in the presence of an acid catalyst. The reaction involves the substitution of a methoxy group for a hydrogen atom on the benzene ring, followed by the replacement of a chlorine atom with a methoxy group. This process yields the compound with high selectivity and good yield.

What industries use 2-Chloro-6-methoxyaniline (CAS: 158966-62-2)?

2-Chloro-6-methoxyaniline (CAS: 158966-62-2) is primarily used in the pharmaceutical industry due to its role as an intermediate in drug synthesis. It is also utilized in the polymer industry for the production of certain resins and coatings. Additionally, it finds applications in the manufacturing of dyes, pigments, and as a precursor in semiconductor device fabrication.

What precautions should be taken when handling 2-Chloro-6-methoxyaniline (CAS: 158966-62-2)?

When handling 2-Chloro-6-methoxyaniline (CAS: 158966-62-2), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a fume hood to minimize exposure. In case of spillage, neutralize the spill with an appropriate base and dispose of the waste according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.