2-Chloro-6-methoxyaniline(CAS: 158966-62-2)

2-Chloro-6-methoxyaniline (CAS: 158966-62-2) is a crystalline solid with a molecular weight of approximately 178.62 g/mol. It has a pKa value of 6.5 and is slightly soluble in water. It is moderately reactive towards nucleophiles and is commonly used in organic synthesis. Its solubility in common organic solvents is relatively low, making it important in various industrial applications.

2-Chloro-6-methoxyaniline (CAS: 158966-62-2) is typically synthesized by the reaction of chloromethylbenzene with methanol in the presence of an acid catalyst. The reaction involves the substitution of a methoxy group for a hydrogen atom on the benzene ring, followed by the replacement of a chlorine atom with a methoxy group. This process yields the compound with high selectivity and good yield.

2-Chloro-6-methoxyaniline (CAS: 158966-62-2) is primarily used in the pharmaceutical industry due to its role as an intermediate in drug synthesis. It is also utilized in the polymer industry for the production of certain resins and coatings. Additionally, it finds applications in the manufacturing of dyes, pigments, and as a precursor in semiconductor device fabrication.

When handling 2-Chloro-6-methoxyaniline (CAS: 158966-62-2), it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. This compound should be handled in a fume hood to minimize exposure. In case of spillage, neutralize the spill with an appropriate base and dispose of the waste according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.