L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine | CAS No. 153045-21-7

L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine

Basic Information

CAS Number

153045-21-7

Molecular Formula

C42H74N10O12S

Molecular Weight

943.18 g/mol

AD

Basic Physical Properties

CC(C)CC(C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC(CCSC)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(C(C)C)C(=O)O)NC(=O)C(CC(=O)N)N

InChI

InChI=1S/C42H74N10O12S/c1-19(2)17-27(47-35(56)25(43)18-29(44)54)37(58)49-31(21(5)6)41(62)52-15-12-13-28(52)38(59)46-26(14-16-65-11)36(57)48-30(20(3)4)39(60)45-23(9)34(55)51-33(24(10)53)40(61)50-32(22(7)8)42(63)64/h19-28,30-33,53H,12-18,43H2,1-11H3,(H2,44,54)(H,45,60)(H,46,59)(H,47,56)(H,48,57)(H,49,58)(H,50,61)(H,51,55)(H,63,64)/t23-,24+,25-,26-,27-,28-,30-,31-,32-,33-/m0/s1

InChIKey

OLLATZWLQXKRHY-JJURSQSHSA-N

LogP

-2.1738000000000044

Topological Polar Surface Area

350.6499999999999 Ų

Hydrogen Bond Donor/Acceptor

13 / 22

Complexity

1700

Synonyms & References

English

  • NSC-724373
  • CID 10306666
  • 153045-21-7
  • 2-[[2-[2-[[2-[[2-[[1-[2-[[2-[(2,4-diamino-4-oxobutanoyl)amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-3-hydroxybutanoyl]amino]-3-methylbutanoic acid
  • NSC724373
  • H-Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val-OH
  • L-Valine,L-asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-
  • CEF20, Cytomegalovirus, CMV pp65 (495-503),NLVPMVATV
  • Human CMV pp65 (495-503)
  • PP65 (495-503) (HUMAN CYTOMEGALOVIRUS)
  • 65 KDA LOWER MATRIX PHOSPHOPROTEIN (495-503) (HUMAN CYTOMEGALOVIRUS)
  • ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL
  • CEF20
  • CEF20,Cytomegalovirus,CMV pp65 (495-503)
  • CMV PP65 (495-503)
  • CMV pp65(495-503) epitope
  • CYTOMEGALOVIRUS
  • cytomegalovirus pp65(495-503) epitope
  • cytomegalovirus pp65p495-503
  • H-ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL-OH
  • NLVPMVATV
  • pp65 (495-503) (huMan cytoMegalovirus),65 kDa Lower Matrix Phosphoprotein (495-503) (huMan cytoMegalovirus)
  • Human CMV pp65
  • CEF20, Cytomegalovirus, CMV pp65 (495-503)

MDL Number

MFCD03790024

FAQ

What are the physical and chemical properties of L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7)?

L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7) is a crystalline compound with a molecular weight of approximately 1128.53 g/mol. It has a high solubility in water but is practically insoluble in organic solvents. Chemically, it is stable under normal conditions but can degrade under strongly acidic or basic conditions. It exhibits minimal reactivity towards common functional groups and has a low melting point of 135-140°C.

How is L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7) typically synthesized?

L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7) is synthesized through a multi-step peptide synthesis process, employing solid-phase peptide synthesis (SPPS) with Fmoc chemistry. Commonly used reagents include Fmoc amino acids, HOBt/NMM coupling agents, and TFA-based cleavage. The synthesis typically has a yield of 70-80%, with high selectivity towards the desired product.

What industries use L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7)?

L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7) is primarily used in the pharmaceutical industry for the development of peptide-based drugs. It may also have applications in polymer science for the synthesis of functional polymers, and in biotechnology for research purposes. Its specificity and biological activity make it valuable in biological research and diagnostic tools.

What precautions should be taken when handling L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7)?

When handling L-Asparaginyl-L-leucyl-L-valyl-L-prolyl-L-methionyl-L-valyl-L-alanyl-L-threonyl-L-valine (CAS: 153045-21-7), use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure that all work is conducted in a well-ventilated fume hood. Spills should be cleaned up immediately with absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.

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