2-Chloro-4-iodo-3-methylpyridine

Basic Information

View in Editor

CAS Number

153034-88-9

Molecular Formula

C6H5ClIN

Molecular Weight

253.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

104.0 to 108.0 deg-C

Boiling Point

274.9℃ at 760 mmHg

Density

1.906

Flash Point

120.053°C

Refractive Index

1.624

SMILES

View in Editor

CC1=C(C=CN=C1Cl)I

InChI

InChI=1S/C6H5ClIN/c1-4-5(8)2-3-9-6(4)7/h2-3H,1H3

InChIKey

WHCRABJNJRAJIP-UHFFFAOYSA-N

LogP

2.6480200000000007

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

99.1

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

H318

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class IRRITANT Class IRRITANT

Sensitiveness

Light Sensitive

Synonyms & References

English

AKOS015851090
AC-33395
FT-0691618
SCHEMBL1117775
CS-W009353
EN300-106188
DS-13257
2-chloro-3-methyl-4-iodopyridine
2-Chloro-4-Iodo-3-Methylpyridne
SY022301
DTXSID90435387
Pyridine, 2-chloro-4-iodo-3-methyl-
2-Chloro-4-iodo-3-picoline
2-Chloro-4-iodo-3-methylpyridine
2-chloro-4-iodo-3-methyl-pyridine
AM62374
A809377
MFCD03095293
C3368
153034-88-9
2-Chloro-4-iodo-3-methylpyridine, 97%
AB13660
WHCRABJNJRAJIP-UHFFFAOYSA-N
2-CHLORO-4-IODO-3-PICOLINE
2-Chloro-4-iodo-3-methyl-pyridine 2-Chloro-4-iodo-3-picoline
2-Chloro-4-iodo-3-methyl-pyridine
2-Chloro-4-iodo-3-methyl-pyridine, 2-Chloro-4-iodo-3-picoline
PubChem17059
TRA0049240
AS04931
VP11303

MDL Number

MFCD03095293

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-4-iodo-3-methylpyridine (CAS: 153034-88-9)?

2-Chloro-4-iodo-3-methylpyridine is a crystalline solid with a molecular weight of approximately 326.03 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is also prone to decomposition at high temperatures.

How is 2-Chloro-4-iodo-3-methylpyridine (CAS: 153034-88-9) typically synthesized?

2-Chloro-4-iodo-3-methylpyridine is usually synthesized via the reaction of 3-methylpyridine with N-chlorosuccinimide and iodine. The reaction involves electrophilic aromatic substitution. Commonly used catalysts include Lewis acids to promote the reaction. The yield is generally moderate, around 70-80%.

What industries use 2-Chloro-4-iodo-3-methylpyridine (CAS: 153034-88-9)?

2-Chloro-4-iodo-3-methylpyridine is primarily used in the pharmaceutical and chemical industries. It serves as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its use in polymers and sensors is also explored, though less common.

What precautions should be taken when handling 2-Chloro-4-iodo-3-methylpyridine (CAS: 153034-88-9)?

Handling 2-Chloro-4-iodo-3-methylpyridine requires caution due to its potential for skin and respiratory irritation. It should be stored in a cool, dry place away from direct sunlight and heat sources. Always use personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation. In case of spill, avoid contact with water and use appropriate absorbents. Always follow the Material Safety Data Sheet (MSDS) for detailed safety instructions.