2-Chloro-4-iodo-3-methylpyridine(CAS: 153034-88-9)

2-Chloro-4-iodo-3-methylpyridine is a crystalline solid with a molecular weight of approximately 326.03 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It is also prone to decomposition at high temperatures.

2-Chloro-4-iodo-3-methylpyridine is usually synthesized via the reaction of 3-methylpyridine with N-chlorosuccinimide and iodine. The reaction involves electrophilic aromatic substitution. Commonly used catalysts include Lewis acids to promote the reaction. The yield is generally moderate, around 70-80%.

2-Chloro-4-iodo-3-methylpyridine is primarily used in the pharmaceutical and chemical industries. It serves as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its use in polymers and sensors is also explored, though less common.

Handling 2-Chloro-4-iodo-3-methylpyridine requires caution due to its potential for skin and respiratory irritation. It should be stored in a cool, dry place away from direct sunlight and heat sources. Always use personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to prevent inhalation. In case of spill, avoid contact with water and use appropriate absorbents. Always follow the Material Safety Data Sheet (MSDS) for detailed safety instructions.