Ethyl 6-methoxy-1H-indole-2-carboxylate

Basic Information

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CAS Number

15050-04-1

Molecular Formula

C12H13NO3

Molecular Weight

219.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

380.2℃/760mmHg

SMILES

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CCOC(=O)C1=CC2=C(N1)C=C(C=C2)OC

InChI

InChI=1S/C12H13NO3/c1-3-16-12(14)11-6-8-4-5-9(15-2)7-10(8)13-11/h4-7,13H,3H2,1-2H3

InChIKey

HYFAOIAKHGVBMX-UHFFFAOYSA-N

LogP

2.3532

Topological Polar Surface Area

51.32000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

257

Synonyms & References

English

Ethyl 6-methoxy-1H-indole-2-carboxylate #
Z293535818
15050-04-1
EN300-56916
Ethyl6-methoxy-1H-indole-2-carboxylate
MFCD01544121
6-Methoxy-1H-indole-2-carboxylic acid ethyl ester
1H-Indole-2-carboxylic acid, 6-methoxy-, ethyl ester
CS-0103593
Indole-2-carboxylic acid, 6-methoxy-, ethyl ester
Ethyl 6-methoxy-2-indolecarboxylate
BB 0262633
SY040111
DTXSID80346514
Ethyl 6-methoxy-1H-indole-2-carboxylate
SCHEMBL1319990
J-518831
ethyl 6-methoxyindole-2-carboxylate
LH0047
LS-04473
Oprea1_681677
AKOS005174370
1H-Indole-2-carboxylicacid, 6-methoxy-, ethyl ester
6-METHOXY-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER
ethyl 6-methoxy-1H-indole-2-carboxylate

MDL Number

MFCD01544121

FAQ

What are the physical and chemical properties of Ethyl 6-methoxy-1H-indole-2-carboxylate (CAS: 15050-04-1)?

Ethyl 6-methoxy-1H-indole-2-carboxylate is a white crystalline solid with a molecular weight of approximately 220.26 g/mol. It has a solubility of about 0.2 g/L in water and is soluble in organic solvents like ethanol and acetone. The compound is relatively stable under normal conditions but can undergo hydrolysis in the presence of water. It shows moderate reactivity towards nucleophiles and can be used as a building block in organic synthesis.

How is Ethyl 6-methoxy-1H-indole-2-carboxylate (CAS: 15050-04-1) typically synthesized?

Ethyl 6-methoxy-1H-indole-2-carboxylate can be synthesized by the reaction of 6-methoxy-1H-indole with ethyl chloroformate in the presence of a base like sodium bicarbonate. The reaction is typically carried out in a sealed tube at room temperature, yielding a high yield of the desired product with good selectivity. This method is commonly used in organic synthesis for the preparation of indole derivatives.

What industries use Ethyl 6-methoxy-1H-indole-2-carboxylate (CAS: 15050-04-1)?

Ethyl 6-methoxy-1H-indole-2-carboxylate is primarily used in the pharmaceutical industry for the development of novel drugs. It is also utilized in the synthesis of organic pigments and dyes, as well as in the formulation of some agrochemicals. Its applications in the field of sensors and semiconductors are also being explored, although on a smaller scale compared to its use in other industries.

What precautions should be taken when handling Ethyl 6-methoxy-1H-indole-2-carboxylate (CAS: 15050-04-1)?

When handling Ethyl 6-methoxy-1H-indole-2-carboxylate, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. The compound should be used in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up with caution, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions to ensure safety and compliance with regulations.