1,2,3,4-Tetrahydro-6-isoquinolinol

Basic Information

View in Editor

CAS Number

14446-24-3

Molecular Formula

C9H11NO

Molecular Weight

149.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

Solid

Melting Point

190.0 to 194.0 deg-C

Boiling Point

313.5°C at 760 mmHg

Density

1.141

Flash Point

169.5℃

Refractive Index

1.582

SMILES

View in Editor

C1CNCC2=C1C=C(C=C2)O

InChI

InChI=1S/C9H11NO/c11-9-2-1-8-6-10-4-3-7(8)5-9/h1-2,5,10-11H,3-4,6H2

InChIKey

SCMZIFSYPJICCV-UHFFFAOYSA-N

LogP

1.0379

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

138

Safety Information

View Safety Information

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

SCMZIFSYPJICCV-UHFFFAOYSA-N
6-Hydroxytetrahydroisochinolin
AC-28820
6-Hydroxy-1,2,3,4-tetrahydroisoquinoline
14446-24-3
BRN 0127578
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline
Q-102330
DTXSID80162711
CS-M3291
H1572
1,2,3,4-Tetrahydro-isoquinolin-6-ol;1,2,3,4-Tetrahydroisoquinolin-6-ol
SY003117
AKOS006333936
MFCD01717047
6WR7DU65P7
1,2,3,4-Tetrahydro-isoquinolin-6-ol
1,2,3,4-tetrahydroisoquinolin-6-ol
FT-0646913
1,2,3,4-Tetrahydro-6-isoquinolinol
Z3018438111
AMY3837
AB09835
SCHEMBL1017452
BDBM50024822
6-ISOQUINOLINOL, 1,2,3,4-TETRAHYDRO-
EN300-96853
CHEMBL310736
1,2,3,4-Tetrahydroisoquinolin-6-ol
1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-OL
H90100

MDL Number

MFCD01717047

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 1,2,3,4-Tetrahydro-6-isoquinolinol (CAS: 14446-24-3)?

1,2,3,4-Tetrahydro-6-isoquinolinol is a white crystalline solid with a molecular weight of approximately 165.21 g/mol. It has a moderate solubility in water and organic solvents. Chemically, it is stable but can react with strong acids and bases. It is a Lewis base and can form coordination complexes with metal ions.

How is 1,2,3,4-Tetrahydro-6-isoquinolinol (CAS: 14446-24-3) typically synthesized?

1,2,3,4-Tetrahydro-6-isoquinolinol can be synthesized by the reduction of 6-isoquinoline carboxylic acid with lithium aluminum hydride (LAH) as the reducing agent. This method provides good yield and selectivity. Other methods include hydrogenation of isoquinoline derivatives in the presence of palladium on carbon.

What industries use 1,2,3,4-Tetrahydro-6-isoquinolinol (CAS: 14446-24-3)?

1,2,3,4-Tetrahydro-6-isoquinolinol is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the chemical industry as a building block for the production of polymers and sensors. Additionally, it is used in the synthesis of functional materials for semiconductors.

What precautions should be taken when handling 1,2,3,4-Tetrahydro-6-isoquinolinol (CAS: 14446-24-3)?

When handling 1,2,3,4-Tetrahydro-6-isoquinolinol, wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight and heat sources. Use a fume hood during preparation and disposal to minimize exposure. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.