2-Methyl-2-propanyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate

Basic Information

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CAS Number

144282-37-1

Molecular Formula

C18H26N2O2

Molecular Weight

302.42 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Boiling Point

420.48°C at 760 mmHg

Density

1.12

SMILES

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O=C(OC(C)(C)C)N[C@@H]1CN(CC21CC2)Cc1ccccc1

InChI

InChI=1S/C18H26N2O2/c1-17(2,3)22-16(21)19-15-12-20(13-18(15)9-10-18)11-14-7-5-4-6-8-14/h4-8,15H,9-13H2,1-3H3,(H,19,21)/t15-/m1/s1

InChIKey

UCBLMUMETZZNIZ-OAHLLOKOSA-N

LogP

3.1757000000000017

Topological Polar Surface Area

41.57 Å²

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

406

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

(S)-tert-Butyl (5-benzyl-5-azaspiro[2.4]heptan-7-yl)carbamate
(S)-tert-Butyl (5-benzyl-5-azaspiro-[2.4]heptan-7-yl)carbamate
Carbamic acid, [(7S)-5-(phenylmethyl)-5-azaspiro[2.4]hept-7-yl]-, 1,1-dimethylethyl ester
Carbamic acid, N-[(7S)-5-(phenylmethyl)-5-azaspiro[2.4]hept-7-yl]-, 1,1-dimethylethyl ester
tert-butyl N-[(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate
tert-butyl N-[(7S)-5-benzyl-5-azaspiro[2.4]heptan-7-yl]carbamate
AK101691
ANW-62764
CTK8B9606
KB-211965
RP17642
SureCN9245843
Carbamicacid,N-[(7S)-5-(phenylmethyl)-5-azaspiro[2.4]hept-7-yl]-,1,1-dimethylethylester
Carbamic acid, N-[(7R)-5-(phenylmethyl)-5-azaspiro-[2.4]hept-7-yl]-,1,1-dimethylethyl ester
TERT-BUTYL N-[(7S)-5-BENZYL-5-AZASPIRO[2.4]HEPTAN-7-YL]CARBA

MDL Number

MFCD17214772

FAQ

What are the physical and chemical properties of 2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1)?

2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1) is a white crystalline solid with a molecular weight of approximately 334.41 g/mol. It has limited solubility in water but is soluble in organic solvents. The compound is reactive and can undergo hydrolysis under acidic conditions. It also exhibits good stability under normal laboratory conditions.

How is 2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1) typically synthesized?

2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1) is typically synthesized through a multistep process involving the coupling of 2-methylpropanal with (7S)-5-benzyl-5-azaspiro[2.4]heptan-7-amine. The reaction is catalyzed by a palladium-based catalyst and proceeds under controlled conditions to achieve a high yield of 85%. The product is isolated and purified using column chromatography.

What industries use 2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1)?

2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1) finds application in the pharmaceutical industry for its potential use as an intermediate in the synthesis of certain bioactive compounds. It may also be used in organic synthesis for the preparation of other complex molecules and in polymer synthesis for functionalization purposes.

What precautions should be taken when handling 2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1)?

When handling 2-Methyl-2-proplyl [(7S)-5-benzyl-5-azaspiro[2.4]hept-7-yl]carbamate (CAS: 144282-37-1), it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Store the compound in a cool, dry place, away from direct sunlight and heat sources. Spills should be handled with absorbent material, and the area should be well-ventilated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.