Nortropine hydrochloride

Basic Information

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CAS Number

14383-51-8

Molecular Formula

C7H14ClNO

Molecular Weight

163.64 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

231-237°C (dec.)

Boiling Point

266.5°C at 760 mmHg

Flash Point

116.8℃

SMILES

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C1CC2CC(CC1N2)O.Cl

InChI

InChI=1S/C7H13NO.ClH/c9-7-3-5-1-2-6(4-7)8-5;/h5-9H,1-4H2;1H

InChIKey

RROJVSOIIWHLCQ-UHFFFAOYSA-N

LogP

0.6835

Topological Polar Surface Area

32.26 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

104

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

endo-8-Azabicyclo(3.2.1)octan-3-ol hydrochloride
A808121
SCHEMBL659022
8-azabicyclo[3.2.1]octan-3-ol;hydrochloride
N-Benzyl-3-(ethoxycarbonyl)-4-piperidonehydrochloride
3-alpha-Nortropanol hydrochloride
MFCD01711246
PB24470
8-Azabicyclo[3.2.1]octan-3-ol, hydrochloride (1:1), (3-endo)-
1-alpha-H,5-alpha-H-Nortropan-3-alpha-ol, hydrochloride
CS-11077
863249-39-2
NSC127743
AKOS015900584
Nortropine hydrochloride
RROJVSOIIWHLCQ-UHFFFAOYSA-N
8-Aza-bicyclo[3.2.1]octan-3-ol hydrochloride
8-azabicyclo[3.2.1]octane-3-ol hydrochloride
W-108166
DTXSID40932119
endo-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride
8-azabicyclo[3.2.1]octan-3-ol hydrochloride
8-Azabicyclo[3.2.1]octan-3-olato(2-)--hydrogen chlorido(2-) (1/1)
EINECS 238-356-6
SY004790
endo-8-Azabicyclo(3.2.1)octan-3-ol HCl
1-Benzyl-4-oxo-piperidine-3-carboxylic acid ethyl ester; hydrochloride
NSC-127743
14383-51-8
Nortropine
nortropine hydrochloride

MDL Number

MFCD01711246

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Nortropine hydrochloride (CAS: 14383-51-8)?

Nortropine hydrochloride (CAS: 14383-51-8) is a white crystalline compound with a molecular weight of approximately 330.82 g/mol. It is highly soluble in water and slightly soluble in ethanol. This compound is less reactive under normal conditions but can decompose under strong acidic or alkaline conditions. It is stable at room temperature but should be stored protected from light to prevent degradation.

How is Nortropine hydrochloride (CAS: 14383-51-8) typically synthesized?

Nortropine hydrochloride (CAS: 14383-51-8) is synthesized through a multi-step process involving the reduction of tropine followed by the conversion to the hydrochloride salt. Common synthetic methods include the use of hydrogenation catalysts like palladium on carbon and subsequent protonation with hydrochloric acid. The yield and selectivity can be influenced by reaction conditions such as temperature and solvent choice.

What industries use Nortropine hydrochloride (CAS: 14383-51-8)?

Nortropine hydrochloride (CAS: 14383-51-8) is primarily used in the pharmaceutical industry for its muscarinic antagonist properties. It is also utilized in research and development for evaluating receptor binding and pharmacological activities. Additionally, it can be used in certain sensor technologies for detecting specific analytes.

What precautions should be taken when handling Nortropine hydrochloride (CAS: 14383-51-8)?

When handling Nortropine hydrochloride (CAS: 14383-51-8), it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up using absorbent materials and disposed of according to local regulations. It is advisable to consult the Safety Data Sheet (SDS) for comprehensive safety information and emergency procedures.