Olanzapine EP Impurity A (Olanzapine USP Related Compound A)

Basic Information

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CAS Number

138564-59-7

Molecular Formula

C12H9N3O2S

Molecular Weight

259.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

109.0 to 115.0 deg-C

Boiling Point

425.4°C at 760 mmHg

Density

1.4±0.1 g/cm3

Flash Point

211.1±28.7 °C

Refractive Index

1.659

Vapor Pressure

0.0±1.0 mmHg at 25°C

SMILES

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CC1=CC(=C(S1)NC2=CC=CC=C2[N+](=O)[O-])C#N

InChI

InChI=1S/C12H9N3O2S/c1-8-6-9(7-13)12(18-8)14-10-4-2-3-5-11(10)15(16)17/h2-6,14H,1H3

InChIKey

NPXUFPFFHANGDL-UHFFFAOYSA-N

LogP

4.17618

Complexity

362

Safety Information

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GHS Hazard Pictograms

H410

Hazard Statement

H410 Very toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

UNII-J7X181M78Y
NCI60_035882
5-methyl-2-(2-nitroanilino)thiophene-3-carbonitrile;5-Methyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile
CS-W010154
3-Thiophenecarbonitrile, 5-methyl-2-[(2-nitrophenyl)amino]-
CHEMBL1990114
3-Thiophenecarbonitrile, 5-methyl-2-((2-nitrophenyl)amino)-
Q27281324
Olanzapine Imp. A (EP); Olanzapine USP Related Compound A; Olanzapine USP RC A; 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile; Olanzapine Related Compound A; Olanzapine Impurity A
2-(2-(Hydroxy(oxido)amino)anilino)-5-methyl-3-thiophenecarbonitrile
5-Methyl-2-((2-nitrophenyl)amino)thiophene-3-carbonitrile
A807401
AR-438/43237645
AMY284
NSC700023
5-Methyl-2-(2-nitrophenylamino)-3-thiophenecarbonitrile
5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile
5-methyl-2-(2-nitroanilino)-3-thiophenecarbonitrile
EN300-304782
J7X181M78Y
Z1422333167
5-Methyl-2-((2-nitrophenyl)amino)-3-thiophenecarbonitrile
SMR002530034
EC 421-300-1
AC-1687
MNPATCN
5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile
3-Cyano-5-methyl-2-(2-nitroanilino)thiophene
NPXUFPFFHANGDL-UHFFFAOYSA-N
2-{2-nitroanilino}-5-methyl-3-thiophenecarbonitrile
F16691

MDL Number

MFCD06408054

Customs Code

2934999090

FAQ

What regulatory guidelines apply to Olanzapine EP Impurity A (CAS: 138564-59-7)?

Olanzapine EP Impurity A (CAS: 138564-59-7) falls under GHS classification and requires compliance with REACH regulations in the European Union. In the US, it is subject to FDA and EPA requirements. Manufacturers must ensure proper labeling, handling, and disposal to meet these regulations.

Are there alternatives to Olanzapine EP Impurity A (CAS: 138564-59-7) in synthesis?

For synthesizing Olanzapine, alternative reagents such as 9-aminoacridine and 2,3-dihydro-1H-inden-1-one are available. These can be used as substitutes to achieve similar outcomes. However, it is important to evaluate their reactivity and compatibility with the rest of the synthesis process.

What is the market or research trend for Olanzapine EP Impurity A (CAS: 138564-59-7)?

The market for Olanzapine EP Impurity A (CAS: 138564-59-7) is driven by the ongoing research and development in antipsychotic medications. There is a growing interest in understanding and reducing impurities to improve drug efficacy and safety. Recent trends show an increased focus on pharmacokinetic studies and clinical trials involving related compounds.

How should waste containing Olanzapine EP Impurity A (CAS: 138564-59-7) be handled?

Waste containing Olanzapine EP Impurity A (CAS: 138564-59-7) should be collected in appropriate containers and handled according to environmental protection regulations. Incineration or professional waste disposal services are recommended. Ensure that all safety and disposal protocols are followed to prevent environmental contamination and ensure worker safety.