Gadoxetate sodium

Basic Information

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CAS Number

135326-22-6

Molecular Formula

C23H28GdN3Na2O11

Molecular Weight

725.71 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CCOC1=CC=C(C=C1)CC(CN(CCN(CC(=O)[O-])CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Gd+3]

InChI

InChI=1S/C23H33N3O11.Gd.2Na/c1-2-37-18-5-3-16(4-6-18)9-17(26(14-22(33)34)15-23(35)36)10-24(11-19(27)28)7-8-25(12-20(29)30)13-21(31)32;;;/h3-6,17H,2,7-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36);;;/q;+3;2*+1/p-5/t17-;;;/m0.../s1

InChIKey

SLYTULCOCGSBBJ-FCQHKQNSSA-I

Complexity

712

Safety Information

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Toxicity

LD50 i.v. in mice: 7.5 mmol/kg (Weinmann)

Synonyms & References

English

Gadoxetate Disodium
Bay 86-4873
Disodium (N-((2S)-2-(bis(carboxymethyl)amino)-3-(p-ethoxyphenyl)propyl)-N-(2-(bis(carboxymethyl)amino)ethyl)glycinato(5-))gadolinate(2-)
Eovist
Eovist injection
Gadolinate(2-), (N-(2-(bis((carboxy-kappaO)methyl)amino-kappaN)-3-(4-ethoxyphenyl)pro
Gadolinium EOB DTPA
gadolinium ethoxybenzyl DTPA
Gadoxetate Disodium [USAN]
Gadoxetic acid disodium
Gd-(S)-EOB-DTPA
Primovist
UNII-HOY74VZE0M
ZK 139834
Gadoxetate
(SA-8-11252634)-[N-[(2S)-2-[bis[(carboxy-?O)methyl-Gadolinate(2-)]amino-?N]-3-(4-ethoxyphenyl)propyl]-N-[2-[bis[(carboxy-?O)methyl]amino-?N]ethyl]glycinato(5-)-?N,?O]
sodium salt (1:2)
Gadolinium Citrate Disodium
135326-22-6
Gadoxetate disodium (USAN)
Gadoxetate sodium (JAN)
D04288
Gadoxetate sodium
disodium;2-[[2-[bis(carboxylatomethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate;gadolinium(3+)
GADOLINIUM(3+) DISODIUM 2-({2-[BIS(CARBOXYLATOMETHYL)AMINO]-3-(4-ETHOXYPHENYL)PROPYL}({2-[BIS(CARBOXYLATOMETHYL)AMINO]ETHYL})AMINO)ACETATE
Eovist (TN)

MDL Number

MFCD22572765

FAQ

What regulatory guidelines apply to Gadoxetate sodium (CAS: 135326-22-6)?

Gadoxetate sodium (CAS: 135326-22-6) is a pharmaceutical agent used in medical imaging. It is subject to various regulatory guidelines including the REACH regulations in the European Union, FDA approval in the United States, and EPA regulations for environmental protection. The substance is classified under GHS (Globally Harmonized System of Classification and Labeling of Chemicals) as a category 2 respiratory sensitizer and category 1B dermal sensitiser.

Are there alternatives to Gadoxetate sodium (CAS: 135326-22-6) in synthesis?

There are several alternatives to Gadoxetate sodium (CAS: 135326-22-6) in the synthesis of contrast agents for medical imaging. Some common alternatives include Gadoteric acid and Gadodiamide. These compounds offer similar functions but may have different GHS classifications and regulatory requirements.

What is the market or research trend for Gadoxetate sodium (CAS: 135326-22-6)?

Gadoxetate sodium (CAS: 135326-22-6) continues to be an important contrast agent in the medical imaging market, particularly for hepatobiliary imaging. Research trends are focused on understanding its pharmacokinetics, improving safety profiles, and exploring new applications in liver and biliary system diagnostics. The demand for this compound is driven by its high specificity and safety in contrast-enhanced MRI.

How should waste containing Gadoxetate sodium (CAS: 135326-22-6) be handled?

Waste containing Gadoxetate sodium (CAS: 135326-22-6) should be collected in appropriate containers and disposed of according to local regulations. Professional waste disposal services are recommended to ensure compliance with environmental protection standards. Proper incineration or other specialized waste disposal methods should be employed, and all handling should follow safety guidelines to prevent exposure and environmental contamination.