(2R)-2-Methylpyrrolidine hydrochloride (1:1)

Basic Information

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CAS Number

135324-85-5

Molecular Formula

C5H12ClN

Molecular Weight

121.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

73.0 to 77.0 deg-C

Boiling Point

100.2°Cat760mmHg

Flash Point

0.5°C

SMILES

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CC1CCCN1.Cl

InChI

InChI=1S/C5H11N.ClH/c1-5-3-2-4-6-5;/h5-6H,2-4H2,1H3;1H/t5-;/m1./s1

InChIKey

JNEIFWYJFOEKIM-NUBCRITNSA-N

LogP

1.1801

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

43.2

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

(2R)-2-METHYLPYRROLIDINE, HCL
2-(R)-methylpyrrolidine HCl
2-(R)-methylpyrrolidine hydrochloride
AKOS005146077
GS-4509
JNEIFWYJFOEKIM-NUBCRITNSA-N
SCHEMBL238775
Pyrrolidine, 2-methyl-, hydrochloride, (2R)-
DTXSID00456821
AM20080260
(R)-2-METHYL-PYRROLIDINE HCL
(2R)-2-methylpyrrolidine;hydrochloride
(R)-2-Methylpyrrolidinehydrochloride
(R)-(-)-2-Methylpyrrolidine HCl
J-502428
2(R)-methylpyrrolidine hydrochloride
(2R)-(-)-2-Methylpyrrolidine hydrochloride
(R)-2-methylpyrrolidine hydrochloride
(r)-2-methyl pyrrolidine hydrochloride
(R)-2-Methyl-pyrrolidine hydrochloride
MFCD06796610
2-(R)Methyl-pyrrolidine hydrochloride
EN300-6496427
135324-85-5
(r)-2-methylpyrrolidine hcl
2-(R)-methyl-pyrrolidine hydrochloride
AC-6782
AKOS015844405
M2747
(2R)-2-methylpyrrolidine Hydrochloride
CS-W019122

MDL Number

MFCD06796610

Customs Code

2933990090

FAQ

What are the physical and chemical properties of (2R)-2-Methylpyrrolidine hydrochloride (CAS: 135324-85-5)?

(2R)-2-Methylpyrrolidine hydrochloride is a colorless to white crystalline solid with a molecular weight of 138.65 g/mol. It has a solubility of 100 mg/mL in water and 50 mg/mL in ethanol. This compound is mildly basic due to its hydrochloride salt form, and it reacts with bases to form pyrrolidine. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

How is (2R)-2-Methylpyrrolidine hydrochloride (CAS: 135324-85-5) typically synthesized?

(2R)-2-Methylpyrrolidine hydrochloride is commonly synthesized by the reaction of 2-methylpyrrolidine with hydrochloric acid. The reaction typically proceeds at room temperature, and the yield is around 85-90%. The use of a catalytic amount of acid can enhance the selectivity and yield of the product.

What industries use (2R)-2-Methylpyrrolidine hydrochloride (CAS: 135324-85-5)?

(2R)-2-Methylpyrrolidine hydrochloride is used in various industries, including pharmaceuticals where it serves as a precursor for drug synthesis, in polymer science for the production of functional polymers, and in the manufacturing of chemical sensors and semiconductors. Its basic nature and structural features make it suitable for these applications.

What precautions should be taken when handling (2R)-2-Methylpyrrolidine hydrochloride (CAS: 135324-85-5)?

When handling (2R)-2-Methylpyrrolidine hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be used in a well-ventilated area or under a fume hood to avoid inhalation. In case of a spill, neutralize the acid with a base and dispose of it according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.