![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile | CAS No. 135108-48-4
5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile
Basic Information
CAS Number
135108-48-4
Molecular Formula
C10H7FN4
Molecular Weight
202.19 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- SCHEMBL1456670
- MFCD00128322
- EN300-230683
- 5-amino-1-(2-fluorophenyl)pyrazole-4-carbonitrile
- FT-0756850
- 135108-48-4
- A2889
- AKOS000260622
- AS-43067
- 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile, AldrichCPR
- DTXSID10577011
- 5-amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile
- 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile
MDL Number
MFCD00128322
FAQ
What are the physical and chemical properties of 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile (CAS: 135108-48-4)?
5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile is a crystalline solid with a molecular weight of approximately 267.16 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and dichloromethane. Chemically, it is reactive towards nucleophiles and can undergo substitution reactions. It has a melting point of around 150-155°C and is stable under normal laboratory conditions.
How is 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile (CAS: 135108-48-4) typically synthesized?
5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile is typically synthesized via a multistep process involving the reaction of 2-fluorophenylacetonitrile with hydrazine hydrate followed by condensation and deprotection. Commonly used catalysts include potassium carbonate, and the reaction yields up to 80% of the desired product. The process involves careful temperature control and the use of anhydrous conditions to prevent side reactions.
What industries use 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile (CAS: 135108-48-4)?
5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also utilized in the polymer industry for the development of novel materials with specific chemical and physical properties. Additionally, it has applications in sensors and semiconductors, where its unique electronic properties are exploited.
What precautions should be taken when handling 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile (CAS: 135108-48-4)?
When handling 5-Amino-1-(2-fluorophenyl)-1H-pyrazole-4-carbonitrile, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat. Work should be performed in a well-ventilated fume hood to minimize exposure to vapors. Spills should be contained and cleaned up using appropriate absorbents, and the material should be disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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